Reactome | phospho-Irs1 [plasma membrane]

phospho-Irs1 [plasma membrane]

Stable Identifier

R-MMU-198366

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-Y-IRS1, P35569

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Mus musculus)
        
        phospho-Irs1 [plasma membrane] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Mus musculus)
        
        phospho-Irs1 [plasma membrane] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - PI3K/AKT activation (Mus musculus)
        
        PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Mus musculus)
        
        phospho-Irs1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P35569 Irs1

Gene Names

Irs1, Irs-1

Chain

chain:1-1233

Reference Genes

BioGPS Gene:16367 Irs1

KEGG Gene (Mus musculus):16367 Irs1

Monarch:16367 Irs1

NCBI Gene:16367 Irs1

Reference Transcript

RefSeq:NM_010570.4 Irs1

Participates

as a member of

Phospho-IRS1/2 (by TRKA) [plasma membrane] (Mus musculus)

Other forms of this molecule

p-Irs1 [cytosol]

phospho-Irs1 [plasma membrane]

Irs1 [plasma membrane]

Phospho-IRS1 (by NTRK1) [cytosol]

Irs1 [cytosol]

phospho-Irs1 [cytosol]

Inferred From

p-Y-IRS1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_034700.2

PRO

P35569

MGI

99454

PDB

5AXI, 1AYB

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26450 Pik3r1	5	p-Y-Pik3r1 [cytosol] (R-MMU-9680631) Pik3r1 [cytosol] (R-MMU-3080572) Pi3k-p85 alpha [cytosol] (R-MMU-1295777) Pik3r1 [cytosol] (R-MMU-74789) Pik3r1 [plasma membrane] (R-MMU-198365)	0.702	3
UniProt:P09405	1	Ncl [nucleoplasm] (R-MMU-6791213)	0.581	3
UniProt:Q1XH17 Trim72	1	Trim72 [cytoplasmic vesicle membrane] (R-MMU-5333009)	0.576	4
UniProt:Q9CQV8 Ywhab	1	14-3-3 beta/alpha [cytosol] (R-MMU-1445100)	0.527	2
UniProt:Q13625-2 TP53BP2			0.524	2
UniProt:P67778	2	Phb1 [mitochondrial inner membrane] (R-MMU-8953720) Phb1 [cytosol] (R-MMU-5672944)	0.462	2
UniProt:Q76MZ3 Ppp2r1a	2	Ppp2r1a [nucleoplasm] (R-MMU-165968) PP2A A subunit [cytosol] (R-MMU-206067)	0.462	2
UniProt:P10922	1	H1-0 [nucleoplasm] (R-MMU-206132)	0.462	2
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-9735212) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) Ctnnb1 [plasma membrane] (R-MMU-9761458) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) Ctnnb1 [plasma membrane] (R-MMU-9038440)	0.462	2

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