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Foxo3 [nucleoplasm]
Stable Identifier
R-MMU-199305
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
FOXO3, Q9WVH4
Locations in the PathwayBrowser for interactor UniProt:Q8WTS6
Expand all
Developmental Biology (Mus musculus)
Signaling by NODAL (Mus musculus)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)
Foxo3 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of FOXO transcriptional activity by acetylation (Mus musculus)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)
Foxo3 [nucleoplasm] (Mus musculus)
SIRT1,SIRT3 deacetylate FOXO3 (Mus musculus)
Foxo3 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
AKT phosphorylates FOXO3 downstream of FLT3 (Mus musculus)
Foxo3 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Mus musculus)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)
Foxo3 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WVH4 Foxo3
Gene Names
Foxo3, Fkhr2, Foxo3a
Chain
chain:1-672
Reference Genes
BioGPS Gene:56484 Foxo3
ENSEMBL:ENSMUSG00000048756 Foxo3
KEGG Gene (Mus musculus):56484 Foxo3
Monarch:56484 Foxo3
NCBI Gene:56484 Foxo3
UCSC:Q9WVH4 Foxo3
Reference Transcript
RefSeq:XM_006512806.1 Foxo3
RefSeq:NM_019740.2 Foxo3
Other Identifiers
10368886
10368888
1434831_a_at
1434832_at
1450236_at
17240529
4357014
4429764
4519412
4575394
4623230
4637115
5189583
5232980
5341345
5473299
5490721
5611582
56484
92958_at
A_51_P145507
A_52_P373852
A_55_P2150896
GE120257
GO:0000003
GO:0000122
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001227
GO:0001228
GO:0001542
GO:0001544
GO:0001547
GO:0001556
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005759
GO:0005829
GO:0006355
GO:0006357
GO:0006390
GO:0006412
GO:0006417
GO:0006914
GO:0006915
GO:0006950
GO:0007165
GO:0007267
GO:0007568
GO:0008013
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008286
GO:0009056
GO:0009058
GO:0010508
GO:0014737
GO:0016020
GO:0019899
GO:0019901
GO:0021700
GO:0030154
GO:0030330
GO:0030336
GO:0031490
GO:0031667
GO:0032991
GO:0033209
GO:0034246
GO:0034599
GO:0034641
GO:0040007
GO:0040011
GO:0042149
GO:0042493
GO:0042592
GO:0042593
GO:0042594
GO:0043065
GO:0043226
GO:0043525
GO:0043565
GO:0045648
GO:0045665
GO:0045893
GO:0045944
GO:0048854
GO:0048856
GO:0048870
GO:0070542
GO:0071333
GO:0071386
GO:0071456
GO:0071548
GO:0090090
GO:0097150
GO:0097192
GO:1901300
GO:1902895
GO:1903428
GO:1904646
GO:1990090
GO:1990785
GO:1990837
GO:2000177
GO:2000353
GO:2000377
ILMN_2439078
ILMN_2501865
ILMN_2690574
ILMN_2772652
mMC003480
mMC014692
mMC014829
Participant Of
input
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
AKT phosphorylates FOXO3 downstream of FLT3
KAT2B,EP300 acetylate FOXO3 under oxidative stress
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements
output
SIRT1,SIRT3 deacetylate FOXO3
hasMember
FOXO1,FOXO3 [nucleoplasm]
FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm]
FOXO3,(FOXO1) [nucleoplasm]
FOXO3,(FOXO1,FOXO4) [nucleoplasm]
FOXO3,FOXO4,(FOXO1) [nucleoplasm]
hasComponent
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]
Other forms of this molecule
phospho-Foxo3 [nucleoplasm]
phospho-Foxo3 [cytosol]
Foxo3 [cytosol]
Foxo3 [nucleoplasm]
Foxo3 [nucleoplasm]
phospho-Foxo3 [cytosol]
phospho-Foxo3 [nucleoplasm]
Inferred From
FOXO3 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_062714.1
,
XP_006512869.1
Ensembl
ENSMUST00000175881
,
ENSMUSP00000050683
,
ENSMUST00000056974
,
ENSMUST00000105502
,
ENSMUSG00000048756
,
ENSMUSP00000101141
,
ENSMUSP00000135380
PRO
Q9WVH4
MGI
1890081
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Foxp3 ENSMUSG00000039521
0.564
2
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.544
5
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