Reactome | RPS6KA2 [nucleoplasm]

RPS6KA2 [nucleoplasm]

Stable Identifier

R-MMU-199861

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q9WUT3

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
      - ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - Nuclear Events (kinase and transcription factor activation) (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        RPS6KA2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9WUT3 Rps6ka2

Gene Names

Rps6ka2, Mapkapk1c, Rsk3

Chain

chain:1-733

Reference Genes

BioGPS Gene:20112 Rps6ka2

ENSEMBL:ENSMUSG00000023809.11 Rps6ka2

KEGG Gene (Mus musculus):20112 Rps6ka2

Monarch:20112 Rps6ka2

NCBI Gene:20112 Rps6ka2

UCSC:Q9WUT3 Rps6ka2

Reference Transcript

RefSeq:NM_011299.4 Rps6ka2

Other Identifiers

10441565

1417542_at

1417543_at

17332974

20112

4616507

98007_at

A_51_P320466

A_55_P1986888

A_55_P2822828

GE36028

GO:0000166

GO:0000287

GO:0001556

GO:0002035

GO:0003013

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005856

GO:0006468

GO:0007507

GO:0008285

GO:0010628

GO:0010659

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0035556

GO:0036211

GO:0043065

GO:0043226

GO:0045786

GO:0045835

GO:0048856

GO:0050877

GO:0050886

GO:0051604

GO:0060047

GO:0070613

GO:0071322

GO:0072687

GO:0106310

GO:0140013

GO:0140096

ILMN_1251886

ILMN_2655510

aa409568_s_at

mMC021803

mMC024458

mMR027135

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)

Other forms of this molecule

p-4S,T356,T570-Rps6ka2 [nucleoplasm]

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]

phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]

Inferred From

RPS6KA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_035429.1

ZINC - Substances

KS6A2_MOUSE

ZINC target

Q9WUT3

Ensembl

ENSMUSP00000024575, ENSMUST00000024575, ENSMUSG00000023809

PRO

Q9WUT3

MGI

1342290

ZINC - Predictions - Purchasable

KS6A2_MOUSE

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