Reactome | phospho-Smad1 [nucleoplasm]

phospho-Smad1 [nucleoplasm]

Stable Identifier

R-MMU-201483

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

p-S463,S465-SMAD1, P70340

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - RUNX2 regulates bone development (Mus musculus)
        
        RUNX2 binds SMAD1 in the nucleus (Mus musculus)
        
        RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Mus musculus)
        
        p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Mus musculus)
        
        phospho-Smad1 [nucleoplasm] (Mus musculus)
        
        p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Mus musculus)
        
        phospho-Smad1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P70340

Gene Names

Smad1

Reference Genes

BioGPS Gene:17125 Smad1

ENSEMBL:ENSMUSG00000031681

ENSEMBL:ENSMUSG00000031681 Smad1

KEGG Gene (Mus musculus):17125 Smad1

Monarch:17125 Smad1

NCBI Gene:17125 Smad1

UCSC:P70340 Smad1

Reference Transcript

Other Identifiers

102983_at

102984_g_at

10579860

1416081_at

1448208_at

1459843_s_at

17125

17510735

4316394

4346836

4685179

5004386

5007074

5380260

5406604

5428570

5484907

5515231

5553649

A_52_P65108

A_55_P2029285

GE118119

GO:0000003

GO:0000165

GO:0000978

GO:0001228

GO:0001657

GO:0001710

GO:0002051

GO:0003674

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005667

GO:0005737

GO:0006355

GO:0006357

GO:0006464

GO:0006468

GO:0006950

GO:0006954

GO:0007165

GO:0007179

GO:0007183

GO:0007276

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0010628

GO:0017151

GO:0019899

GO:0019901

GO:0022607

GO:0030154

GO:0030509

GO:0030901

GO:0030902

GO:0032991

GO:0034641

GO:0040007

GO:0042493

GO:0042592

GO:0042802

GO:0043167

GO:0043226

GO:0043565

GO:0045597

GO:0045669

GO:0045944

GO:0046872

GO:0048646

GO:0048856

GO:0051216

GO:0060038

GO:0060348

GO:0060395

GO:0061036

GO:0065003

GO:0070410

GO:0070411

GO:0070878

GO:0071407

GO:0071773

GO:1901522

GO:1902895

GO:1903672

ILMN_1234354

ILMN_2671572

ILMN_2953700

mMC018812

u74359_s_at

Participant Of

hasMember

Phospho-R-SMAD1/5/9 [nucleoplasm]

hasComponent

p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]

Other forms of this molecule

Smad1 [cytosol]

phospho-Smad1 [cytosol]

Inferred From

p-S463,S465-SMAD1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 463 (in Homo sapiens)

Coordinate

463

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 465 (in Homo sapiens)

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_032565.2, XP_006530809.1

Ensembl

ENSMUSG00000031681, ENSMUSP00000071035, ENSMUST00000066091

PRO

P70340

MGI

109452

PDB

3KMP

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62073 Map3k7	10	Map3k7 [cytosol] (R-MMU-6782968) Phospho TAK1 [cytosol] (R-MMU-205840) phospho-Map3k7 [cytosol] (R-MMU-206014) Map3k7 [cytosol] (R-MMU-5607643) phospho-Map3k7 [cytosol] (R-MMU-5607649) phospho-Map3k7 [cytosol] (R-MMU-168163) Map3k7 [endosome membrane] (R-MMU-450315) phospho-Map3k7 [endosome membrane] (R-MMU-450332) Map3k7 [cytosol] (R-MMU-168156) phospho-Map3k7 [cytosol] (R-MMU-202527)	0.602	3