Reactome | Csnk2a1 [cytosol]

Csnk2a1 [cytosol]

Stable Identifier

R-MMU-201713

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CSNK2A1, Q60737

Locations in the PathwayBrowser

Expand all

Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - Selective autophagy (Mus musculus)
    - Mitophagy (Mus musculus)
      - Receptor Mediated Mitophagy (Mus musculus)
        
        FUNDC1 is phosphorylated by CK2 (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - Condensation of Prometaphase Chromosomes (Mus musculus)
        
        CK2 phosphorylates condensin I subunits (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Cell-Cell communication (Mus musculus)

- Cell junction organization (Mus musculus)
  - Cell-cell junction organization (Mus musculus)
    - Adherens junctions interactions (Mus musculus)
      - Regulation of Homotypic Cell-Cell Adhesion (Mus musculus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Mus musculus)
        
        Regulation of CDH1 Expression and Function (Mus musculus)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Mus musculus)
        
        Cytosolic tail of CDH1 is phosphorylated (Mus musculus)
        
        (CK2) [cytosol] (Mus musculus)
        
        CK2 (A1:A2:B) [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CK2 (A1:B) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Signal transduction by L1 (Mus musculus)
        
        Phosphorylation of L1 by CK-II (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        pL1:CK-II [plasma membrane] (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-inhibition by PD-1 (Mus musculus)
      - Regulation of PD-L1(CD274) expression (Mus musculus)
        
        Regulation of PD-L1(CD274) Post-translational modification (Mus musculus)
        
        SPOP-mediated proteasomal degradation of PD-L1(CD274) (Mus musculus)
        
        CK2 phosphorylates CD274 (Mus musculus)
        
        CK2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Metabolism (Mus musculus)

- Metabolism of lipids (Mus musculus)
  - Phospholipid metabolism (Mus musculus)
    - Glycerophospholipid biosynthesis (Mus musculus)
      - Synthesis of PC (Mus musculus)
        
        Casein kinase II phosphorylates STARD10 (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Protein folding (Mus musculus)
  - Chaperonin-mediated protein folding (Mus musculus)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Mus musculus)
      - CK2 phosphorylates PDCL (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN stability and activity (Mus musculus)
        
        Casein kinase II phosphorylates PTEN (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
- Signaling by WNT (Mus musculus)
  - TCF dependent signaling in response to WNT (Mus musculus)
    - WNT mediated activation of DVL (Mus musculus)
      - CSNK2-mediated phosphorylation of DVL (Mus musculus)
        
        Casein kinase II [cytosol] (Mus musculus)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Mus musculus)
        
        CSNK2A1 dimer [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)
        
        CSNK2A1:CSNK2A2 [cytosol] (Mus musculus)
        
        Csnk2a1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60737 Csnk2a1

Gene Names

Csnk2a1, Ckiia

Chain

chain:1-391

Reference Genes

BioGPS Gene:12995 Csnk2a1

KEGG:mmu:12995 Csnk2a1

Monarch:12995 Csnk2a1

NCBI Gene:12995 Csnk2a1

UCSC:Q60737 Csnk2a1

Reference Transcript

Other Identifiers

103441_at

10350819

104545_at

104546_g_at

10477073

12995

1419034_at

1419035_s_at

1419036_at

1419037_at

1419038_a_at

1453427_at

160690_at

17377675

4343851

4355918

4373156

4379715

4550603

4562626

4569508

4574773

4582624

4799505

4825238

4830900

4862381

4919046

4955245

4982695

4997229

5022426

5035329

5049312

5051172

5056118

5067912

5081235

5229974

5276465

5284746

5287019

5296137

5356969

5366626

5376616

5427086

5435955

5495188

5503086

5552949

5585018

A_51_P397768

A_52_P131997

A_52_P513959

A_55_P1971828

A_55_P2022840

A_55_P2022845

A_55_P2721124

GE36389

GO:0000166

GO:0000785

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005829

GO:0005956

GO:0006281

GO:0006302

GO:0006468

GO:0006915

GO:0008013

GO:0008284

GO:0016055

GO:0016301

GO:0016740

GO:0019888

GO:0021987

GO:0030177

GO:0030307

GO:0031519

GO:0033574

GO:0043021

GO:0045732

GO:0048511

GO:0048856

GO:0051726

GO:0097421

GO:0106310

GO:0140096

GO:1903076

GO:1905337

GO:1905818

GO:2000042

GO:2001234

ILMN_1218670

ILMN_1223808

aa266026_s_at

mMC015208

u51866_s_at

Participates

as a component of

Other forms of this molecule

Csnk2a1 [nucleoplasm]

CK2alpha [cytosol]

Inferred From

CSNK2A3 [cytosol] (Homo sapiens)

CSNK2A1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001403895.1, XP_006498720.1, NP_001403896.1, NP_031814.2, NP_001403894.1, NP_001403900.1, XP_011237574.1, NP_001403899.1, XP_030102934.1, NP_001403897.1, NP_001403898.1

ENSEMBL

ENSMUST00000099224, ENSMUSG00000074698, ENSMUSP00000096829

ZINC - Substances

CSK21_MOUSE

ZINC target

Q60737

PRO

Q60737

GlyGen

Q60737

MGI

88543

ZINC - Predictions - Purchasable

CSK21_MOUSE

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9WTL8 Bmal1	7	p-S97-Bmal1 [nucleoplasm] (R-MMU-9920676) Arntl [cytosol] (R-MMU-508660) p-S97-Bmal1 [cytosol] (R-MMU-9912402) p-S-Arntl [nucleoplasm] (R-MMU-508690) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624) p-S97,Ac-544-Bmal1 [nucleoplasm] (R-MMU-9920664)	0.499	5
UniProt:P67871 Csnk2b	6	Csnk2b [ficolin-1-rich granule lumen] (R-MMU-6801290) Csnk2b [extracellular region] (R-MMU-6806508) Csnk2b [secretory granule lumen] (R-MMU-6801319) CK2beta [cytosol] (R-MMU-205908) Csnk2b [nucleoplasm] (R-MMU-9923134) Csnk2b [cytosol] (R-MMU-201693)	0.499	5

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