Reactome | phospho-Lck [plasma membrane]

phospho-Lck [plasma membrane]

Stable Identifier

R-MMU-202159

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-Y505-LCK, P06240

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P06240 Lck

Gene Names

Lck, Lsk-t

Chain

initiator methionine:, chain:2-509

Reference Genes

BioGPS Gene:16818 Lck

KEGG:mmu:16818 Lck

Monarch:16818 Lck

NCBI Gene:16818 Lck

UCSC:P06240 Lck

Reference Transcript

Other Identifiers

102809_s_at

10516620

1425396_a_at

1439145_at

1439146_s_at

16818

17430413

4365171

4400266

4406208

4558922

4568065

4636803

4671941

4683421

4695333

4810598

4814668

4988917

5150457

5186492

5290956

5293679

5343788

5394055

5394720

5400253

5463215

5549197

5565059

A_51_P141288

A_55_P2506985

GE112706

GE1466813

GO:0000242

GO:0001772

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0004722

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006882

GO:0007166

GO:0009410

GO:0010628

GO:0016020

GO:0016740

GO:0016787

GO:0019903

GO:0030154

GO:0030217

GO:0042169

GO:0042492

GO:0042609

GO:0045121

GO:0045588

GO:0045589

GO:0050853

GO:0050856

GO:0050870

GO:0051209

GO:0055085

GO:0140096

GO:1990405

GO:2001244

ILMN_1224526

ILMN_2651137

mMC001127

x03533_s_at

Participates

as a component of

Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-Lck [plasma membrane]

Lck [cytosol]

phospho-Lck [cytosol]

Lck [cytosol]

Inferred From

p-Y505-LCK [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 505 (in Homo sapiens)

Coordinate

505

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006502881.1, NP_001155905.1, NP_034823.1

ZINC - Investigational

LCK_MOUSE

ZINC - World Drugs

LCK_MOUSE

ENSEMBL

ENSMUST00000067240, ENSMUSP00000099656, ENSMUSP00000066209, ENSMUST00000102596, ENSMUSG00000000409

ZINC - FDA approved

LCK_MOUSE

ZINC - Substances

LCK_MOUSE

ZINC target

P06240

PRO

P06240

MGI

96756

ZINC - Predictions - Purchasable

LCK_MOUSE

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49710 HCLS1			0.704	6
UniProt:P06332	2	Cd4 [clathrin-coated endocytic vesicle membrane] (R-MMU-8869082) Cd4 [plasma membrane] (R-MMU-167542)	0.681	3
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
UniProt:P06800	2	Ptprc [secretory granule membrane] (R-MMU-6806150) Ptprc [plasma membrane] (R-MMU-197931)	0.59	2
UniProt:O92972 POLG			0.589	2
UniProt:P01731	1	Cd8a [plasma membrane] (R-MMU-197601)	0.573	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.558	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.524	2
UniProt:Q9QXK9	1	Sh2d2a [cytosol] (R-MMU-4420125)	0.508	3