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phospho-p-Y505-LCK [plasma membrane]
Stable Identifier
R-MMU-202159
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
P06240
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
TCR signaling (Mus musculus)
Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
phospho-p-Y505-LCK [plasma membrane] (Mus musculus)
Inactivation of Lck by Csk (Mus musculus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
phospho-p-Y505-LCK [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P06240 Lck
Gene Names
Lck, Lsk-t
Chain
initiator methionine:1, chain:2-509
Reference Genes
BioGPS Gene:16818 Lck
dbSNP Gene:16818 Lck
ENSEMBL:ENSMUSG00000000409 Lck
KEGG Gene (Mus musculus):16818 Lck
Monarch:16818 Lck
NCBI Gene:16818 Lck
UCSC:P06240 Lck
Reference Transcript
RefSeq:XM_006502818.3 Lck
RefSeq:NM_010693.3 Lck
RefSeq:NM_001162433.1 Lck
Other Identifiers
04660+2.7.10.2
102809_s_at
10516620
1425396_a_at
1439146_s_at
16818
17430413
192010
192011
4365171
4400266
4406208
4558922
4568065
4636803
4683421
4810598
4988917
5290956
5293679
5343788
5394055
5400253
5549197
5565059
A_51_P141288
AAA39421
AAA39422
AAB59674
AAH11474
AK088001
B2KG65
BAC40086
BC011474
CAA27234
CAA27235
CAA27236
CCDS18697
E9Q696
ENSMUSG00000000409
ENSMUSP00000066209
ENSMUSP00000099656
ENSMUST00000067240
ENSMUST00000102596
EntrezGene:16818
EntrezGene:Lck
GE112706
GO:0000166
GO:0000242
GO:0001772
GO:0001784
GO:0002376
GO:0003674
GO:0003823
GO:0004672
GO:0004713
GO:0004715
GO:0004722
GO:0005102
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0006464
GO:0006468
GO:0006470
GO:0006810
GO:0006882
GO:0006919
GO:0006950
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0008022
GO:0008150
GO:0008219
GO:0009612
GO:0010038
GO:0010628
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0016791
GO:0018108
GO:0019899
GO:0019901
GO:0019903
GO:0030139
GO:0030154
GO:0030217
GO:0031234
GO:0031410
GO:0034116
GO:0038083
GO:0042169
GO:0042493
GO:0042531
GO:0042542
GO:0042592
GO:0042608
GO:0042609
GO:0042610
GO:0042802
GO:0043167
GO:0043226
GO:0043548
GO:0044877
GO:0045121
GO:0045588
GO:0045589
GO:0046777
GO:0048856
GO:0050853
GO:0050856
GO:0050870
GO:0051117
GO:0051209
GO:0055085
GO:0070474
GO:0098978
GO:0099091
GO:1903039
GO:1990405
GO:2001244
ILMN_1224526
ILMN_2651137
IPR000719
IPR000980
IPR001245
IPR001452
IPR008266
IPR011009
IPR017441
IPR020635
IPR035749
IPR035850
IPR036028
IPR036860
Lck
Lck-201
Lck-202
M12056
M18098
M21511
MGI:96756
mMC001127
NM_001162433
NM_010693
NP_001155905
NP_034823
PF00017
PF00018
PF07714
PR00109
PR00401
PR00452
SM00219
SM00252
SM00326
uc008uxi.2
uc008uxj.2
UPI000000418D
X03533
x03533_s_at
XM_006502818
XP_006502881
Participant Of
hasComponent
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane]
Other forms of this molecule
phospho-p-Y394-LCK [plasma membrane]
Lck [cytosol]
phospho-p-Y394-LCK [cytosol]
LCK [cytosol]
Inferred From
p-Y505-LCK [plasma membrane] (Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 505 (in Homo sapiens)
Coordinate
505
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ZINC - Investigational
LCK_MOUSE
RefSeq
XP_006502881.1
,
NP_001155905.1
,
NP_034823.1
ZINC - World Drugs
LCK_MOUSE
ZINC - FDA approved
LCK_MOUSE
ZINC - Substances
LCK_MOUSE
ZINC target
P06240
PRO
P06240
ZINC - Predictions - Purchasable
LCK_MOUSE
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06332
2
CD4 [plasma membrane]
(R-MMU-167542)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869082)
0.681
3
UniProt:P27958 Genome polyprotein
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.656
3
UniProt:P06800
2
PTPRC [plasma membrane]
(R-MMU-197931)
PTPRC [secretory granule membrane]
(R-MMU-6806150)
0.59
2
UniProt:Q63767
4
phospho-p-Y12-BCAR1 [cytosol]
(R-RNO-5218739)
phospho-p-Y-BCAR1 [cytosol]
(R-RNO-372645)
phospho-p-Y165,Y664-BCAR1 [cytosol]
(R-RNO-8848723)
BCAR1 [cytosol]
(R-RNO-201625)
0.558
2
UniProt:P22681 CBL
6
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
CBL [cytosol]
(R-HSA-112199)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.524
2
UniProt:Q9QXK9
1
SH2D2A [cytosol]
(R-MMU-4420125)
0.508
3
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