Reactome | phospho-Cd3e [plasma membrane]

phospho-Cd3e [plasma membrane]

Stable Identifier

R-MMU-202228

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-Y188,Y199-CD3E, P22646

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Costimulation by the CD28 family (Mus musculus)
    - PD-1 signaling (Mus musculus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Generation of second messenger molecules (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
      - Phosphorylation of SLP-76 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
      - Phosphorylation of TBSMs in LAT (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
    - Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
    - Translocation of ZAP-70 to Immunological synapse (Mus musculus)
      - Activation of ZAP-70 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
      - PTPN22 dephosphorylates ZAP70 (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
      - Phosphorylation of ZAP-70 by Lck (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Mus musculus)
        
        phospho-Cd3e [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P22646

Gene Names

Cd3e

Reference Genes

BioGPS Gene:12501 Cd3e

ENSEMBL:ENSMUSG00000032093

ENSEMBL:ENSMUSG00000032093.8 Cd3e

KEGG Gene (Mus musculus):12501 Cd3e

Monarch:12501 Cd3e

NCBI Gene:12501 Cd3e

UCSC:P22646 Cd3e

Reference Transcript

Other Identifiers

102971_at

10593024

12501

1422105_at

17526464

4526240

4660171

4677490

5123922

5133040

5343671

5355380

5420245

A_51_P455681

A_55_P2156229

GE34828

GO:0001772

GO:0001954

GO:0002250

GO:0002376

GO:0002669

GO:0002870

GO:0004888

GO:0005515

GO:0005783

GO:0005794

GO:0005886

GO:0005911

GO:0007155

GO:0007166

GO:0007224

GO:0007584

GO:0009897

GO:0010628

GO:0010629

GO:0012501

GO:0016020

GO:0016358

GO:0017124

GO:0019722

GO:0021549

GO:0023052

GO:0030154

GO:0031295

GO:0032729

GO:0032743

GO:0032753

GO:0033634

GO:0035739

GO:0036211

GO:0042098

GO:0042101

GO:0042102

GO:0042105

GO:0042110

GO:0042802

GO:0043197

GO:0043226

GO:0044297

GO:0045059

GO:0045060

GO:0045879

GO:0046649

GO:0048856

GO:0050731

GO:0050850

GO:0050852

GO:0050870

GO:0060089

GO:0097190

GO:2000563

ILMN_1238847

ILMN_2784580

j02990_s_at

mMC022581

Participates

as a component of

Other forms of this molecule

Cd3e [plasma membrane]

Inferred From

p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 188 (in Homo sapiens)

Coordinate

188

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 199 (in Homo sapiens)

Coordinate

199

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006510029.1, NP_031674.1

Ensembl

ENSMUSP00000099896, ENSMUST00000102832, ENSMUSG00000032093

PRO

P22646

MGI

88332

PDB

3R08, 1XMW, 2K4F, 1JBJ

Cite Us!