Reactome | Axin1 [cytosol]

Axin1 [cytosol]

Stable Identifier

R-MMU-205727

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

External Reference Information

External Reference

UniProt:O35625 Axin1

Gene Names

Axin1, Axin, Fu

Chain

chain:1-863

Reference Genes

BioGPS Gene:12005 Axin1

KEGG Gene (Mus musculus):12005 Axin1

Monarch:12005 Axin1

NCBI Gene:12005 Axin1

Reference Transcript

RefSeq:NM_009733.2 Axin1

Participates

as a component of

as an input of

as an output of

Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin (Mus musculus)

Other forms of this molecule

Phospho Axin1 [cytosol]

Axin1 [cytosol]

phospho-Axin1 [cytosol]

Phospho (3 sites) Axin1 [cytosol]

phospho-Axin1 [cytosol]

Axin1 [cytosol]

Cross References

RefSeq

NP_033863.2

PRO

O35625

MGI

1096327

PDB

3UTM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02248 Ctnnb1	12	phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363)	0.725	9
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.688	4
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.659	5
UniProt:P98078	3	Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [cytosol] (R-MMU-8862456) Dab2 [plasma membrane] (R-MMU-2980808)	0.656	4
UniProt:Q9WV60 Gsk3b	3	Gsk3b [cytosol] (R-MMU-2997551) GSK3beta [cytosol] (R-MMU-206095) Gsk3b [nucleoplasm] (R-MMU-182565)	0.589	2
UniProt:O75581 LRP6	8	p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.589	2
UniProt:Q99ML9 Rnf111	3	Rnf111 [nucleoplasm] (R-MMU-2186735) Rnf111 [cytosol] (R-MMU-975981) Rnf111 [nucleoplasm] (R-MMU-2186765)	0.581	4
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.581	4
UniProt:O88572	5	phospho-Lrp6 [early endosome membrane] (R-MMU-5368496) Lrp6 [early endosome membrane] (R-MMU-5368481) phospho-Lrp6 [plasma membrane] (R-MMU-1458894) phospho-Lrp6 [plasma membrane] (R-MMU-1458895) Lrp6 [plasma membrane] (R-MMU-206252)	0.527	5
UniProt:P46937 YAP1	7	p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.524	3
UniProt:Q61062	4	Dvl3 [cytosol] (R-MMU-201678) Dvl3 [cytosol] (R-MMU-4652688) phospho-Dvl3 [cytosol] (R-MMU-201680) phospho-Dvl3 [cytosol] (R-MMU-3772400)	0.499	2
UniProt:Q9EPK5 Wwtr1	4	phospho-Wwtr1 [cytosol] (R-MMU-2028665) Wwtr1 [nucleoplasm] (R-MMU-2064930) Wwtr1 [cytosol] (R-MMU-1629773) Wwtr1 [nucleoplasm] (R-MMU-1629775)	0.499	4

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