Reactome | Jak2 [cytosol]

Jak2 [cytosol]

Stable Identifier

R-MMU-205743

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

External Reference Information

External Reference

UniProt:Q62120 Jak2

Gene Names

Jak2

Chain

chain:1-1129

Reference Genes

BioGPS Gene:16452 Jak2

KEGG Gene (Mus musculus):16452 Jak2

Monarch:16452 Jak2

NCBI Gene:16452 Jak2

Reference Transcript

Participant Of

hasComponent

input

output

Dephosphorylation of Jaks by Ptps

hasMember

Jak1, Jak2, Tyk2 [cytosol]

Other forms of this molecule

p-Jak2 [cytosol]

phospho-p-JAK2 [cytosol]

phospho-p-Y1007,Y1008-JAK2 [cytosol]

phospho-p-Y813-JAK2 [cytosol]

JAK2 [endosome lumen]

p-Y1007-Jak2 [cytosol]

p-12Y-Jak2 [cytosol]

phospho-p-12Y-JAK2 [cytosol]

JAK2 [cytosol]

phospho-p-Y1007-JAK2 [cytosol]

Cross References

RefSeq

NP_032439.2, NP_001041642.1

ZINC - World Drugs

JAK2_MOUSE

ZINC - FDA approved

JAK2_MOUSE

ZINC - Substances

JAK2_MOUSE

ZINC target

Q62120

PRO

Q62120

ZINC - Predictions - Purchasable

JAK2_MOUSE

PDB

4GL9, 2HDX

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q91ZM2 Sh2b1	2	SH2B1-2 [cytosol] (R-MMU-1675482) Sh2b1 [cytosol] (R-MMU-2671856)	0.667	3
UniProt:P46527 CDKN1B	8	p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.626	7
UniProt:P14753 Epor	3	p-8Y-Epor [plasma membrane] (R-MMU-9006275) EpoR [plasma membrane] (R-MMU-206154) phospho-p-8Y-EPOR [plasma membrane] (R-MMU-9006274)	0.589	4
UniProt:P48356 Lepr			0.524	3
UniProt:Q5VWK5 IL23R	2	IL23R [plasma membrane] (R-HSA-447156) p-Y-IL23R [plasma membrane] (R-HSA-8950616)	0.499	2
UniProt:O35716 Socs1	2	SOCS1 [cytosol] (R-MMU-204910) Socs1 [cytosol] (R-MMU-912674)	0.482	2
UniProt:P10686 Plcg1	8	phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) p-Plcg1 [plasma membrane] (R-RNO-182042) PLCG1 [cytosol] (R-RNO-202320) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.463	3

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