Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Jak2 [cytosol]
Stable Identifier
R-MMU-205743
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
External Reference Information
External Reference
UniProt:Q62120 Jak2
Gene Names
Jak2
Chain
chain:1-1129
Reference Genes
BioGPS Gene:16452 Jak2
KEGG Gene (Mus musculus):16452 Jak2
Monarch:16452 Jak2
NCBI Gene:16452 Jak2
Reference Transcript
RefSeq:NM_008413.3 Jak2
RefSeq:NM_001048177.2 Jak2
Participant Of
hasComponent
Epor:Jak2:Lyn:Irs2 [plasma membrane]
Growth hormone:Tyrosine phosphorylated growth hormone receptor-Jak2 dimer:SHP1 [plasma membrane]
Growth hormone:Tyrosine phosphorylated growth hormone receptor-Jak2 dimer:SHP2 [plasma membrane]
IL12RB2:Jak2 [plasma membrane]
Il23r:Jak2 [plasma membrane]
IL3RB:Jak2 [plasma membrane]
JAK2:EpoR [plasma membrane]
Lepr:Jak2 [plasma membrane]
input
IL12RB2 binds Jak2
Il23r binds Jak2
Mouse JAK2 binds human common beta chain
Murine JAK2 binds to the Erythropoietin receptor, EpoR
output
Dephosphorylation of Jaks by Ptps
hasMember
Jak1, Jak2, Tyk2 [cytosol]
Other forms of this molecule
phospho-Jak2 [cytosol]
Jak2 [cytosol]
phospho-Jak2 [cytosol]
p-12Y-Jak2 [cytosol]
p-Y1007-Jak2 [cytosol]
Jak2 [endosome lumen]
phospho-Jak2 [cytosol]
phospho-Jak2 [cytosol]
phospho-Jak2 [cytosol]
p-Jak2 [cytosol]
Cross References
RefSeq
NP_001041642.1
,
NP_032439.2
ZINC - World Drugs
JAK2_MOUSE
ZINC - FDA approved
JAK2_MOUSE
ZINC - Substances
JAK2_MOUSE
ZINC target
Q62120
PRO
Q62120
MGI
96629
ZINC - Predictions - Purchasable
JAK2_MOUSE
PDB
2HDX
,
4GL9
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q91ZM2 Sh2b1
2
Sh2b1 [cytosol]
(R-MMU-1675482)
Sh2b1 [cytosol]
(R-MMU-2671856)
0.667
3
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.626
7
UniProt:P14753 Epor
3
p-8Y-Epor [plasma membrane]
(R-MMU-9006275)
EpoR [plasma membrane]
(R-MMU-206154)
phospho-Epor [plasma membrane]
(R-MMU-9006274)
0.589
4
UniProt:P48356 Lepr
0.524
3
UniProt:Q5VWK5 IL23R
2
IL23R [plasma membrane]
(R-HSA-447156)
p-Y-IL23R [plasma membrane]
(R-HSA-8950616)
0.499
2
UniProt:O35716 Socs1
2
Socs1 [cytosol]
(R-MMU-204910)
Socs1 [cytosol]
(R-MMU-912674)
0.482
2
UniProt:P10686 Plcg1
8
phospho-Plcg1 [plasma membrane]
(R-RNO-1169084)
p-4Y-Plcg1 [plasma membrane]
(R-RNO-9034825)
Plcg1 [plasma membrane]
(R-RNO-182093)
Plcg1 [plasma membrane]
(R-RNO-167682)
p-Plcg1 [plasma membrane]
(R-RNO-182042)
Plcg1 [cytosol]
(R-RNO-202320)
phospho-Plcg1 [cytosol]
(R-RNO-202357)
phospho-Plcg1 [plasma membrane]
(R-RNO-167679)
0.463
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text