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Ywhaz [cytosol]
Stable Identifier
R-MMU-206099
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
YWHAZ, P63101
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of localization of FOXO transcription factors (Mus musculus)
14-3-3 proteins bind AKT-phosphorylated FOXO1 (Mus musculus)
YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Mus musculus)
YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Mus musculus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
DDIT4 binds 14-3-3 dimer (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
DDIT4:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
DDIT4:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GP1b-IX-V activation signalling (Mus musculus)
14-3-3-zeta binds Raf1 (Mus musculus)
14-3-3-zeta:Raf1 [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
GP1b-IX-V binds 14-3-3-zeta (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Rap1 signalling (Mus musculus)
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)
14-3-3 beta, zeta [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
RAP1GAP2:14-3-3beta, zeta [cytosol] (Mus musculus)
14-3-3 beta, zeta [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Rap1 signal termination by Rap1GAPs (Mus musculus)
RAP1GAP2:14-3-3beta, zeta [cytosol] (Mus musculus)
14-3-3 beta, zeta [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-S585-IL3RB binds 14-3-3 proteins (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation of BH3-only proteins (Mus musculus)
Activation of BAD and translocation to mitochondria (Mus musculus)
Activation of BAD by calcineurin (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Sequestration of BAD protein by 14-3-3 (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by NOTCH (Mus musculus)
Signaling by NOTCH4 (Mus musculus)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Mus musculus)
NICD4 traffics to the nucleus (Mus musculus)
p-4S-NICD4:YWHAZ dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PKNs (Mus musculus)
Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
YWHAZ dimer [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Deactivation of the beta-catenin transactivating complex (Mus musculus)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol] (Mus musculus)
Ywhaz [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P63101 Ywhaz
Gene Names
Ywhaz
Chain
chain:1-245
Reference Genes
BioGPS Gene:22631 Ywhaz
ENSEMBL:ENSMUSG00000022285 Ywhaz
KEGG Gene (Mus musculus):22631 Ywhaz
Monarch:22631 Ywhaz
NCBI Gene:22631 Ywhaz
UCSC:P63101 Ywhaz
Reference Transcript
RefSeq:NM_001253806.1 Ywhaz
RefSeq:NM_001253805.1 Ywhaz
RefSeq:XM_011245352.2 Ywhaz
RefSeq:NM_011740.3 Ywhaz
Other Identifiers
10428204
10493891
1416102_at
1416103_at
1436971_x_at
1448218_s_at
1448219_a_at
17316545
17399904
22631
4318872
4406267
4492368
4496281
4644992
4671887
4737754
4832503
5026454
5034564
5144777
5175395
5219991
5220935
5252476
5313247
5341467
5341673
5383375
5420151
5427389
5432839
5473754
5593786
97544_at
A_52_P225260
A_55_P1987245
A_66_P120770
GE36295
GO:0002376
GO:0002553
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005829
GO:0006464
GO:0006468
GO:0006605
GO:0006626
GO:0006810
GO:0006950
GO:0007005
GO:0007165
GO:0007267
GO:0008039
GO:0008134
GO:0008150
GO:0008219
GO:0010941
GO:0014069
GO:0015031
GO:0016192
GO:0019899
GO:0019901
GO:0019904
GO:0021700
GO:0022607
GO:0030154
GO:0031252
GO:0031410
GO:0031625
GO:0032991
GO:0034330
GO:0042470
GO:0042493
GO:0042629
GO:0042802
GO:0043226
GO:0044325
GO:0044877
GO:0048471
GO:0048856
GO:0051683
GO:0070372
GO:0090128
GO:0090168
GO:0098686
GO:0098978
ILMN_2510612
ILMN_2952914
Msa.11098.0_i_at
d78647_s_at
mMC020595
Participant Of
hasMember
14-3-3 beta, zeta [cytosol]
input
p-S585-IL3RB binds 14-3-3 proteins
hasComponent
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane]
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [cytosol]
YWHAZ dimer [cytosol]
Other forms of this molecule
Ywhaz [nucleoplasm]
14-3-3zeta [cytosol]
Inferred From
YWHAZ [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001240734.1
,
NP_001240735.1
,
XP_011243654.1
,
NP_035870.1
Ensembl
ENSMUSP00000105991
,
ENSMUST00000022894
,
ENSMUSP00000105990
,
ENSMUSP00000022894
,
ENSMUST00000110362
,
ENSMUST00000110361
,
ENSMUSG00000022285
PRO
P63101
MGI
109484
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S006
1
Lrrk2 [cytosol]
(R-MMU-5661173)
0.677
5
IntAct:EBI-1179609 H3
0.639
17
UniProt:Q9QWV4 MLF1
0.632
3
UniProt:Q92945 KHSRP
4
p-T692-KHSRP [cytosol]
(R-HSA-451177)
p-S193-KHSRP [nucleoplasm]
(R-HSA-450452)
p-S193-KHSRP [cytosol]
(R-HSA-450505)
KSRP [cytosol]
(R-HSA-450485)
0.592
2
UniProt:Q61097
5
Ksr1 [cytosol]
(R-MMU-5672587)
phospho-Ksr1 [cytosol]
(R-MMU-5672654)
phospho-Ksr1 [cytosol]
(R-MMU-5672652)
phospho-Ksr1 [plasma membrane]
(R-MMU-5672659)
phospho-Ksr1 [cytosol]
(R-MMU-5672656)
0.547
2
UniProt:O35929 REM1
0.544
2
UniProt:Q99LC3
1
Ndufa10 [mitochondrial inner membrane]
(R-MMU-163937)
0.527
2
UniProt:P56480
2
Atp5f1b [mitochondrial matrix]
(R-MMU-164576)
Atp5f1b [mitochondrial matrix]
(R-MMU-8986172)
0.527
2
UniProt:P35486
2
Pdha1 [mitochondrial matrix]
(R-MMU-8953513)
Pdha1 [mitochondrial matrix]
(R-MMU-69966)
0.527
2
UniProt:P11499
5
Hsp90ab1 [extracellular region]
(R-MMU-6806463)
Hsp90ab1 [ficolin-1-rich granule lumen]
(R-MMU-6801491)
Hsp90ab1 [secretory granule lumen]
(R-MMU-6801477)
Hsp90ab1 [cytosol]
(R-MMU-419617)
Hsp90ab1 [nucleoplasm]
(R-MMU-5082399)
0.527
2
UniProt:Q9CQ75
1
Ndufa2 [mitochondrial inner membrane]
(R-MMU-60178)
0.527
2
UniProt:P67778
2
Phb [cytosol]
(R-MMU-5672944)
Phb [mitochondrial inner membrane]
(R-MMU-8953720)
0.527
2
UniProt:P35564 Canx
3
Canx [integral component of lumenal side of endoplasmic reticulum membrane]
(R-MMU-983091)
Calnexin [integral component of lumenal side of endoplasmic reticulum membrane]
(R-MMU-983099)
Canx [endoplasmic reticulum lumen]
(R-MMU-195906)
0.527
2
UniProt:P30275
1
Ckmt1 [mitochondrial inner membrane]
(R-MMU-200361)
0.527
2
UniProt:P50518
1
Atp6v1e1 [cytosol]
(R-MMU-912606)
0.527
2
UniProt:Q8K2B3
1
Sdha [mitochondrial inner membrane]
(R-MMU-70983)
0.527
2
UniProt:P14824 Anxa6
1
Anxa6 [cytosol]
(R-MMU-5332995)
0.527
2
UniProt:P97807
1
Fh [mitochondrial matrix]
(R-MMU-70980)
0.527
2
UniProt:Q8VCE0 Q8VCE0
0.527
2
UniProt:P07901 Hsp90aa1
7
Hsp90aa1 [extracellular region]
(R-MMU-3221946)
Hsp90aa1 [ficolin-1-rich granule lumen]
(R-MMU-6801470)
Hsp90aa1 [secretory granule lumen]
(R-MMU-6801515)
Hsp90aa1 [plasma membrane]
(R-MMU-534996)
Hsp90aa1 [nucleoplasm]
(R-MMU-5082401)
Hsp90aa1 [cytosol]
(R-MMU-5605275)
Hsp90aa1 [cytosol]
(R-MMU-192864)
0.527
2
UniProt:P15105
1
Glul [cytosol]
(R-MMU-70603)
0.527
2
UniProt:P05064
6
Aldoa [ficolin-1-rich granule lumen]
(R-MMU-6801521)
Aldoa [platelet alpha granule lumen]
(R-MMU-349738)
Aldoa [secretory granule lumen]
(R-MMU-6801469)
Aldoa [extracellular region]
(R-MMU-349735)
Aldoa [tertiary granule lumen]
(R-MMU-6801485)
Aldoa [cytosol]
(R-MMU-71492)
0.527
2
UniProt:Q68FD5
6
Cltc [cytosol]
(R-MMU-350824)
Cltc [lysosomal membrane]
(R-MMU-2980660)
Cltc [trans-Golgi network membrane]
(R-MMU-2130474)
Cltc [endolysosome membrane]
(R-MMU-8870827)
Cltc [clathrin-coated endocytic vesicle membrane]
(R-MMU-5138450)
Cltc [plasma membrane]
(R-MMU-2980668)
0.527
2
UniProt:P17742
3
Ppia [secretory granule lumen]
(R-MMU-6801400)
Ppia [ficolin-1-rich granule lumen]
(R-MMU-6801391)
Ppia [extracellular region]
(R-MMU-173646)
0.527
2
UniProt:P40142
1
Tkt [cytosol]
(R-MMU-71321)
0.527
2
UniProt:P63242
3
Eif5a [cytosol]
(R-MMU-3006308)
Eif5a [cytosol]
(R-MMU-3006310)
Eif5a [cytosol]
(R-MMU-3006309)
0.527
2
UniProt:Q03265
1
Atp5f1a [mitochondrial matrix]
(R-MMU-164575)
0.527
2
UniProt:O08749
1
Dld [mitochondrial matrix]
(R-MMU-69978)
0.527
2
UniProt:Q8R0Y6
1
phospho-Aldh1l1 [cytosol]
(R-MMU-6808507)
0.527
2
UniProt:F6SEU4
1
Syngap1 [cytosol]
(R-MMU-5658217)
0.527
2
UniProt:P63017 Hspa8
10
Hspa8 [ficolin-1-rich granule lumen]
(R-MMU-6801494)
Hspa8 [nucleoplasm]
(R-MMU-8932217)
Hspa8 [extracellular region]
(R-MMU-6805936)
Hspa8 [secretory granule lumen]
(R-MMU-6801530)
Hspa8 [nucleoplasm]
(R-MMU-5082380)
Hspa8 [plasma membrane]
(R-MMU-936508)
Hspa8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-MMU-888599)
Hspa8 [late endosome lumen]
(R-MMU-9631087)
Hspa8 [cytosol]
(R-MMU-9613512)
Hspa8 [cytosol]
(R-MMU-264476)
0.527
2
UniProt:Q7TPR4
3
Actn1 [platelet alpha granule lumen]
(R-MMU-349724)
Actn1 [extracellular region]
(R-MMU-349722)
Actn1 [cytosol]
(R-MMU-354096)
0.527
2
UniProt:Q01853 Vcp
8
Vcp [nucleoplasm]
(R-MMU-5643745)
Vcp [cytosol]
(R-MMU-8932209)
Vcp [azurophil granule lumen]
(R-MMU-6800438)
Vcp [ficolin-1-rich granule lumen]
(R-MMU-6800425)
Vcp [extracellular region]
(R-MMU-6806191)
Vcp [secretory granule lumen]
(R-MMU-6801039)
Vcp [cytosol]
(R-MMU-9646344)
Vcp [cytosol]
(R-MMU-1181251)
0.527
2
UniProt:P16546
6
Sptan1 [extracellular region]
(R-MMU-6806322)
Sptan1 [specific granule lumen]
(R-MMU-6799533)
Sptan1 [tertiary granule lumen]
(R-MMU-6800874)
Sptan1 [cytosol]
(R-MMU-202964)
Sptan1 [cytosol]
(R-MMU-202944)
Sptan1 [cytosol]
(R-MMU-201601)
0.527
2
UniProt:Q99LX0
5
Park7 [nucleoplasm]
(R-MMU-3900141)
Park7 [nucleoplasm]
(R-MMU-4085351)
Park7 [cytosol]
(R-MMU-9641100)
Park7 [cytosol]
(R-MMU-9641123)
Park7 [cytosol]
(R-MMU-9641128)
0.527
2
UniProt:P58252
9
Eef2 [cytosol]
(R-MMU-156901)
Eef2 [cytosol]
(R-MMU-8932237)
Eef2 [cytosol]
(R-MMU-5358501)
Eef2 [cytosol]
(R-MMU-5358472)
Eef2 [cytosol]
(R-MMU-5367025)
Eef2 [cytosol]
(R-MMU-5358478)
Eef2 [ficolin-1-rich granule lumen]
(R-MMU-6801513)
Eef2 [extracellular region]
(R-MMU-6806499)
Eef2 [secretory granule lumen]
(R-MMU-6801504)
0.527
2
UniProt:Q8K1M6
2
Dnm1l [cytosol]
(R-MMU-351943)
Dnm1l [mitochondrial outer membrane]
(R-MMU-351942)
0.527
2
UniProt:P46460
1
Nsf [cytosol]
(R-MMU-264471)
0.527
2
UniProt:Q9DCT2
1
Ndufs3 [mitochondrial matrix]
(R-MMU-163927)
0.527
2
UniProt:Q9DB77
1
Uqcrc2 [mitochondrial inner membrane]
(R-MMU-164280)
0.527
2
UniProt:P62814
1
Atp6v1b2 [cytosol]
(R-MMU-912598)
0.527
2
UniProt:P08228 Sod1
6
2xHC-Sod1 [mitochondrial intermembrane space]
(R-MMU-3780969)
Sod1 [extracellular region]
(R-MMU-350705)
Sod1 [mitochondrial intermembrane space]
(R-MMU-3780972)
Sod1 [mitochondrial intermembrane space]
(R-MMU-3777108)
Sod1 [cytosol]
(R-MMU-350697)
Sod1 [cytosol]
(R-MMU-3299726)
0.527
2
UniProt:Q9DCX2
1
Atp5pd [mitochondrial inner membrane]
(R-MMU-50522)
0.527
2
UniProt:Q9EQH3
1
Vps35 [cytosol]
(R-MMU-3247740)
0.527
2
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