Reactome | Ywhaz [cytosol]

Ywhaz [cytosol]

Stable Identifier

R-MMU-206099

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

YWHAZ, P63101

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)

Programmed Cell Death (Mus musculus)

- Apoptosis (Mus musculus)
  - Intrinsic Pathway for Apoptosis (Mus musculus)
    - Activation of BH3-only proteins (Mus musculus)
      - Activation of BAD and translocation to mitochondria (Mus musculus)
        
        Activation of BAD by calcineurin (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        Sequestration of BAD protein by 14-3-3 (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        Ywhaz [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P63101 Ywhaz

Gene Names

Ywhaz

Chain

chain:1-245

Reference Genes

BioGPS Gene:22631 Ywhaz

ENSEMBL:ENSMUSG00000022285 Ywhaz

KEGG Gene (Mus musculus):22631 Ywhaz

Monarch:22631 Ywhaz

NCBI Gene:22631 Ywhaz

UCSC:P63101 Ywhaz

Reference Transcript

Other Identifiers

10428204

10493891

1416102_at

1416103_at

1436971_x_at

1448218_s_at

1448219_a_at

17316545

17399904

22631

4318872

4406267

4492368

4496281

4644992

4671887

4737754

4832503

5026454

5034564

5144777

5175395

5219991

5220935

5252476

5313247

5341467

5341673

5383375

5420151

5427389

5432839

5473754

5593786

97544_at

A_52_P225260

A_55_P1987245

A_66_P120770

GE36295

GO:0002376

GO:0002553

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0006464

GO:0006468

GO:0006605

GO:0006626

GO:0006810

GO:0006950

GO:0007005

GO:0007165

GO:0007267

GO:0008039

GO:0008134

GO:0008150

GO:0008219

GO:0010941

GO:0014069

GO:0015031

GO:0016192

GO:0019899

GO:0019901

GO:0019904

GO:0021700

GO:0022607

GO:0030154

GO:0031252

GO:0031410

GO:0031625

GO:0032991

GO:0034330

GO:0042470

GO:0042493

GO:0042629

GO:0042802

GO:0043226

GO:0044325

GO:0044877

GO:0048471

GO:0048856

GO:0051683

GO:0070372

GO:0090128

GO:0090168

GO:0098686

GO:0098978

ILMN_2510612

ILMN_2952914

Msa.11098.0_i_at

d78647_s_at

mMC020595

Participant Of

hasMember

14-3-3 beta, zeta [cytosol]

input

p-S585-IL3RB binds 14-3-3 proteins

hasComponent

Other forms of this molecule

Ywhaz [nucleoplasm]

14-3-3zeta [cytosol]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001240734.1, NP_001240735.1, XP_011243654.1, NP_035870.1

Ensembl

ENSMUST00000110362, ENSMUST00000022894, ENSMUSP00000105990, ENSMUSP00000022894, ENSMUSP00000105991, ENSMUST00000110361, ENSMUSG00000022285

PRO

P63101

MGI

109484

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S006	1	Lrrk2 [cytosol] (R-MMU-5661173)	0.677	5
IntAct:EBI-1179609 H3			0.639	17
UniProt:Q9QWV4 MLF1			0.632	3
UniProt:Q92945 KHSRP	4	p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.592	2
UniProt:Q61097	5	Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672654) phospho-Ksr1 [cytosol] (R-MMU-5672656) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672652)	0.547	2
UniProt:O35929 REM1			0.544	2
UniProt:Q99LC3	1	Ndufa10 [mitochondrial inner membrane] (R-MMU-163937)	0.527	2
UniProt:P56480	2	Atp5f1b [mitochondrial matrix] (R-MMU-164576) Atp5f1b [mitochondrial matrix] (R-MMU-8986172)	0.527	2
UniProt:P35486	2	Pdha1 [mitochondrial matrix] (R-MMU-8953513) Pdha1 [mitochondrial matrix] (R-MMU-69966)	0.527	2
UniProt:Q9CQ75	1	Ndufa2 [mitochondrial inner membrane] (R-MMU-60178)	0.527	2
UniProt:P67778	2	Phb [cytosol] (R-MMU-5672944) Phb [mitochondrial inner membrane] (R-MMU-8953720)	0.527	2
UniProt:P30275	1	Ckmt1 [mitochondrial inner membrane] (R-MMU-200361)	0.527	2
UniProt:P50518	1	Atp6v1e1 [cytosol] (R-MMU-912606)	0.527	2
UniProt:Q8K2B3	1	Sdha [mitochondrial inner membrane] (R-MMU-70983)	0.527	2
UniProt:P97807	1	Fh [mitochondrial matrix] (R-MMU-70980)	0.527	2
UniProt:Q8VCE0 Q8VCE0			0.527	2
UniProt:Q7TPR4	3	Actn1 [platelet alpha granule lumen] (R-MMU-349724) Actn1 [extracellular region] (R-MMU-349722) Actn1 [cytosol] (R-MMU-354096)	0.527	2
UniProt:P58252	9	Eef2 [cytosol] (R-MMU-156901) Eef2 [cytosol] (R-MMU-8932237) Eef2 [cytosol] (R-MMU-5358501) Eef2 [cytosol] (R-MMU-5358472) Eef2 [cytosol] (R-MMU-5367025) Eef2 [cytosol] (R-MMU-5358478) Eef2 [secretory granule lumen] (R-MMU-6801504) Eef2 [extracellular region] (R-MMU-6806499) Eef2 [ficolin-1-rich granule lumen] (R-MMU-6801513)	0.527	2
UniProt:P15105	1	Glul [cytosol] (R-MMU-70603)	0.527	2
UniProt:P05064	6	Aldoa [tertiary granule lumen] (R-MMU-6801485) Aldoa [platelet alpha granule lumen] (R-MMU-349738) Aldoa [secretory granule lumen] (R-MMU-6801469) Aldoa [extracellular region] (R-MMU-349735) Aldoa [ficolin-1-rich granule lumen] (R-MMU-6801521) Aldoa [cytosol] (R-MMU-71492)	0.527	2
UniProt:Q68FD5	6	Cltc [cytosol] (R-MMU-350824) Cltc [lysosomal membrane] (R-MMU-2980660) Cltc [trans-Golgi network membrane] (R-MMU-2130474) Cltc [endolysosome membrane] (R-MMU-8870827) Cltc [clathrin-coated endocytic vesicle membrane] (R-MMU-5138450) Cltc [plasma membrane] (R-MMU-2980668)	0.527	2
UniProt:P40142	1	Tkt [cytosol] (R-MMU-71321)	0.527	2
UniProt:P63242	3	Eif5a [cytosol] (R-MMU-3006308) Eif5a [cytosol] (R-MMU-3006310) Eif5a [cytosol] (R-MMU-3006309)	0.527	2
UniProt:Q03265	1	Atp5f1a [mitochondrial matrix] (R-MMU-164575)	0.527	2
UniProt:O08749	1	Dld [mitochondrial matrix] (R-MMU-69978)	0.527	2
UniProt:Q8R0Y6	1	phospho-Aldh1l1 [cytosol] (R-MMU-6808507)	0.527	2
UniProt:F6SEU4	1	Syngap1 [cytosol] (R-MMU-5658217)	0.527	2
UniProt:Q9EQH3	1	Vps35 [cytosol] (R-MMU-3247740)	0.527	2
UniProt:Q9DCX2	1	Atp5pd [mitochondrial inner membrane] (R-MMU-50522)	0.527	2
UniProt:P08228 Sod1	6	2xHC-Sod1 [mitochondrial intermembrane space] (R-MMU-3780969) Sod1 [extracellular region] (R-MMU-350705) Sod1 [mitochondrial intermembrane space] (R-MMU-3780972) Sod1 [mitochondrial intermembrane space] (R-MMU-3777108) Sod1 [cytosol] (R-MMU-350697) Sod1 [cytosol] (R-MMU-3299726)	0.527	2
UniProt:Q01853 Vcp	8	Vcp [nucleoplasm] (R-MMU-5643745) Vcp [cytosol] (R-MMU-8932209) Vcp [secretory granule lumen] (R-MMU-6801039) Vcp [azurophil granule lumen] (R-MMU-6800438) Vcp [extracellular region] (R-MMU-6806191) Vcp [ficolin-1-rich granule lumen] (R-MMU-6800425) Vcp [cytosol] (R-MMU-9646344) Vcp [cytosol] (R-MMU-1181251)	0.527	2
UniProt:P11499	5	Hsp90ab1 [extracellular region] (R-MMU-6806463) Hsp90ab1 [secretory granule lumen] (R-MMU-6801477) Hsp90ab1 [ficolin-1-rich granule lumen] (R-MMU-6801491) Hsp90ab1 [cytosol] (R-MMU-419617) Hsp90ab1 [nucleoplasm] (R-MMU-5082399)	0.527	2
UniProt:P35564 Canx	3	Canx [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-983091) Calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-983099) Canx [endoplasmic reticulum lumen] (R-MMU-195906)	0.527	2
UniProt:P16546	6	Sptan1 [extracellular region] (R-MMU-6806322) Sptan1 [tertiary granule lumen] (R-MMU-6800874) Sptan1 [specific granule lumen] (R-MMU-6799533) Sptan1 [cytosol] (R-MMU-202964) Sptan1 [cytosol] (R-MMU-202944) Sptan1 [cytosol] (R-MMU-201601)	0.527	2
UniProt:P46460	1	Nsf [cytosol] (R-MMU-264471)	0.527	2
UniProt:P07901 Hsp90aa1	7	Hsp90aa1 [extracellular region] (R-MMU-3221946) Hsp90aa1 [secretory granule lumen] (R-MMU-6801515) Hsp90aa1 [ficolin-1-rich granule lumen] (R-MMU-6801470) Hsp90aa1 [plasma membrane] (R-MMU-534996) Hsp90aa1 [nucleoplasm] (R-MMU-5082401) Hsp90aa1 [cytosol] (R-MMU-5605275) Hsp90aa1 [cytosol] (R-MMU-192864)	0.527	2
UniProt:Q9DCT2	1	Ndufs3 [mitochondrial matrix] (R-MMU-163927)	0.527	2
UniProt:Q8K1M6	2	Dnm1l [cytosol] (R-MMU-351943) Dnm1l [mitochondrial outer membrane] (R-MMU-351942)	0.527	2
UniProt:P63017 Hspa8	10	Hspa8 [secretory granule lumen] (R-MMU-6801530) Hspa8 [nucleoplasm] (R-MMU-8932217) Hspa8 [extracellular region] (R-MMU-6805936) Hspa8 [ficolin-1-rich granule lumen] (R-MMU-6801494) Hspa8 [nucleoplasm] (R-MMU-5082380) Hspa8 [plasma membrane] (R-MMU-936508) Hspa8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-MMU-888599) Hspa8 [late endosome lumen] (R-MMU-9631087) Hspa8 [cytosol] (R-MMU-9613512) Hspa8 [cytosol] (R-MMU-264476)	0.527	2
UniProt:P17742	3	Ppia [ficolin-1-rich granule lumen] (R-MMU-6801391) Ppia [secretory granule lumen] (R-MMU-6801400) Ppia [extracellular region] (R-MMU-173646)	0.527	2
UniProt:Q99LX0	5	Park7 [nucleoplasm] (R-MMU-3900141) Park7 [nucleoplasm] (R-MMU-4085351) Park7 [cytosol] (R-MMU-9641100) Park7 [cytosol] (R-MMU-9641123) Park7 [cytosol] (R-MMU-9641128)	0.527	2
UniProt:P14824 Anxa6	1	Anxa6 [cytosol] (R-MMU-5332995)	0.527	2
UniProt:Q9DB77	1	Uqcrc2 [mitochondrial inner membrane] (R-MMU-164280)	0.527	2
UniProt:P62814	1	Atp6v1b2 [cytosol] (R-MMU-912598)	0.527	2

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