Reactome | YWHAZ [cytosol]

YWHAZ [cytosol]

Stable Identifier

R-MMU-206099

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P63101

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)

Programmed Cell Death (Mus musculus)

- Apoptosis (Mus musculus)
  - Intrinsic Pathway for Apoptosis (Mus musculus)
    - Activation of BH3-only proteins (Mus musculus)
      - Activation of BAD and translocation to mitochondria (Mus musculus)
        
        Activation of BAD by calcineurin (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)
        
        Sequestration of BAD protein by 14-3-3 (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
        
        14-3-3 dimer [cytosol] (Mus musculus)
        
        YWHAZ dimer [cytosol] (Mus musculus)
        
        YWHAZ [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P63101 Ywhaz

Gene Names

Ywhaz

Chain

chain:1-245

Reference Genes

BioGPS Gene:22631 Ywhaz

ENSEMBL:ENSMUSG00000022285 Ywhaz

KEGG Gene (Mus musculus):22631 Ywhaz

Monarch:22631 Ywhaz

NCBI Gene:22631 Ywhaz

UCSC:P63101 Ywhaz

Reference Transcript

Other Identifiers

10428204

10493891

1416102_at

1416103_at

1436971_x_at

1448218_s_at

1448219_a_at

17316545

17399904

22631

227200

227201

227202

4318872

4406267

4492368

4496281

4644992

4671887

4737754

4832503

5026454

5034564

5144777

5175395

5219991

5220935

5252476

5313247

5341467

5341673

5383375

5420151

5427389

5432839

5473754

5593786

97544_at

A0A2I3BQ03

A_52_P225260

A_55_P1987245

A_66_P120770

AAC53254

AAH50891

AAH89334

AK083368

AK145657

AK146800

AK150381

AK151900

AK162099

AK167128

BAA11464

BAA11751

BAA13421

BAC38887

BAE26570

BAE27442

BAE29512

BAE30783

BAE36724

BAE39275

BC050891

BC089334

CCDS27432

D3YW45

D3YXF4

D3YXN6

D78647

d78647_s_at

D83037

D87660

ENSMUSG00000022285

ENSMUSP00000022894

ENSMUSP00000105990

ENSMUSP00000105991

ENSMUST00000022894

ENSMUST00000022894.13

ENSMUST00000110361

ENSMUST00000110361.7

ENSMUST00000110362

ENSMUST00000110362.3

EntrezGene:22631

EntrezGene:Ywhaz

GE36295

GO:0002376

GO:0002553

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0006605

GO:0006626

GO:0006810

GO:0006950

GO:0007005

GO:0007267

GO:0008039

GO:0008134

GO:0008150

GO:0008219

GO:0010941

GO:0014069

GO:0015031

GO:0016192

GO:0019899

GO:0019901

GO:0019904

GO:0021700

GO:0022607

GO:0030154

GO:0031252

GO:0031410

GO:0031625

GO:0032991

GO:0042470

GO:0042493

GO:0042629

GO:0042802

GO:0043226

GO:0044325

GO:0044877

GO:0048471

GO:0048856

GO:0051683

GO:0090128

GO:0090168

GO:0098686

GO:0098978

ILMN_2510612

ILMN_2952914

IPR000308

IPR023409

IPR023410

IPR036815

MGI:109484

mMC020595

Msa.11098.0_i_at

NM_001253805

NM_001253806

NM_001253807

NM_011740

NP_001240734

NP_001240735

NP_001240736

NP_001343498

NP_035870

PF00244

PR00305

SM00101

U79231

UPI0000004169

XM_011245352

XP_011243654

Ywhaz

Ywhaz-201

Ywhaz-203

Ywhaz-204

Participant Of

hasMember

14-3-3 beta, zeta [cytosol]

input

p-S585-IL3RB binds 14-3-3 proteins

hasComponent

Other forms of this molecule

YWHAZ [nucleoplasm]

14-3-3zeta [cytosol]

Inferred From

YWHAZ [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001240734.1, NP_001240735.1, XP_011243654.1, NP_035870.1

PRO

P63101

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S006	1	LRRK2 [cytosol] (R-MMU-5661173)	0.677	5
IntAct:EBI-1179609 H3			0.639	17
UniProt:Q9QWV4 MLF1			0.632	3
UniProt:Q92945 KHSRP	4	p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.592	2
UniProt:Q61097	5	KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y552 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y552 KSR1 [cytosol] (R-MMU-5672656)	0.547	2
UniProt:O35929 REM1			0.544	2
UniProt:P63017 Hspa8	10	HSPA8 [plasma membrane] (R-MMU-936508) Me3K561-HSPA8 [nucleoplasm] (R-MMU-8932217) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-MMU-888599) HSPA8 [secretory granule lumen] (R-MMU-6801530) HSPA8 [extracellular region] (R-MMU-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-MMU-6801494) HSPA8 [nucleoplasm] (R-MMU-5082380) Hspa8 [late endosome lumen] (R-MMU-9631087) Hspa8 [cytosol] (R-MMU-9613512) HSPA8 [cytosol] (R-MMU-264476)	0.527	2
UniProt:Q99LC3	1	NDUFA10 [mitochondrial inner membrane] (R-MMU-163937)	0.527	2
UniProt:P56480	2	ATP5B [mitochondrial matrix] (R-MMU-164576) ATP5B(1-47) [mitochondrial matrix] (R-MMU-8986172)	0.527	2
UniProt:P35486	2	PDHA2 [mitochondrial matrix] (R-MMU-8953513) PDHA1 [mitochondrial matrix] (R-MMU-69966)	0.527	2
UniProt:P16546	6	SPTAN1 [extracellular region] (R-MMU-6806322) SPTAN1 [specific granule lumen] (R-MMU-6799533) SPTAN1 [tertiary granule lumen] (R-MMU-6800874) SPTAN1(1186-2472) [cytosol] (R-MMU-202964) SPTAN1(1-1185) [cytosol] (R-MMU-202944) SPTAN1 [cytosol] (R-MMU-201601)	0.527	2
UniProt:P11499	5	HSP90AB1 [extracellular region] (R-MMU-6806463) HSP90AB1 [secretory granule lumen] (R-MMU-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-MMU-6801491) HSP90AB1 [cytosol] (R-MMU-419617) HSP90AB1 [nucleoplasm] (R-MMU-5082399)	0.527	2
UniProt:Q9CQ75	1	NDUFA2 [mitochondrial inner membrane] (R-MMU-60178)	0.527	2
UniProt:P30275	1	CKMT1A [mitochondrial inner membrane] (R-MMU-200361)	0.527	2
UniProt:P50518	1	ATP6V1E1 [cytosol] (R-MMU-912606)	0.527	2
UniProt:Q8K2B3	1	SDHA [mitochondrial inner membrane] (R-MMU-70983)	0.527	2
UniProt:P97807	1	FH [mitochondrial matrix] (R-MMU-70980)	0.527	2
UniProt:Q01853 Vcp	8	VCP [nucleoplasm] (R-MMU-5643745) Me3K315-VCP [cytosol] (R-MMU-8932209) VCP [azurophil granule lumen] (R-MMU-6800438) VCP [secretory granule lumen] (R-MMU-6801039) VCP [extracellular region] (R-MMU-6806191) VCP [ficolin-1-rich granule lumen] (R-MMU-6800425) Vcp [cytosol] (R-MMU-9646344) VCP [cytosol] (R-MMU-1181251)	0.527	2
UniProt:P46460	1	NSF [cytosol] (R-MMU-264471)	0.527	2
UniProt:Q8VCE0 Q8VCE0			0.527	2
UniProt:Q8K1M6	2	DNM1L [cytosol] (R-MMU-351943) DNM1L [mitochondrial outer membrane] (R-MMU-351942)	0.527	2
UniProt:P15105	1	GLUL [cytosol] (R-MMU-70603)	0.527	2
UniProt:P67778	2	PHB [cytosol] (R-MMU-5672944) PHB [mitochondrial inner membrane] (R-MMU-8953720)	0.527	2
UniProt:Q99LX0	5	PARK7 [nucleoplasm] (R-MMU-3900141) SUMO1-K130-PARK7 [nucleoplasm] (R-MMU-4085351) Ub-Misfolded PARK7 [cytosol] (R-MMU-9641123) Misfolded PARK7 [cytosol] (R-MMU-9641100) PolyUb-Misfolded PARK7 [cytosol] (R-MMU-9641128)	0.527	2
UniProt:P14824 Anxa6	1	Anxa6 [cytosol] (R-MMU-5332995)	0.527	2
UniProt:P35564 Canx	3	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-983091) Calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-983099) CANX [endoplasmic reticulum lumen] (R-MMU-195906)	0.527	2
UniProt:P58252	9	nascent EEF2 [cytosol] (R-MMU-5358472) Me3K525-EEF2 [cytosol] (R-MMU-8932237) aminocarboxypropyl EEF2 [cytosol] (R-MMU-5358478) Me-diphthine EEF2 [cytosol] (R-MMU-5367025) diphthine EEF2 [cytosol] (R-MMU-5358501) EEF2 [cytosol] (R-MMU-156901) EEF2 [secretory granule lumen] (R-MMU-6801504) EEF2 [extracellular region] (R-MMU-6806499) EEF2 [ficolin-1-rich granule lumen] (R-MMU-6801513)	0.527	2
UniProt:Q7TPR4	3	ACTN1 [platelet alpha granule lumen] (R-MMU-349724) ACTN1 [extracellular region] (R-MMU-349722) ACTN1 [cytosol] (R-MMU-354096)	0.527	2
UniProt:P07901 Hsp90aa1	7	HSP90AA1 [extracellular region] (R-MMU-3221946) HSP90AA1 [secretory granule lumen] (R-MMU-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-MMU-6801470) HSP90AA1 [plasma membrane] (R-MMU-534996) HSP90AA1 [nucleoplasm] (R-MMU-5082401) Hsp90aa1 [cytosol] (R-MMU-5605275) HSP90AA1 [cytosol] (R-MMU-192864)	0.527	2
UniProt:P17742	3	PPIA [ficolin-1-rich granule lumen] (R-MMU-6801391) PPIA [secretory granule lumen] (R-MMU-6801400) PPIA [extracellular region] (R-MMU-173646)	0.527	2
UniProt:Q9DCT2	1	NDUFS3 [mitochondrial matrix] (R-MMU-163927)	0.527	2
UniProt:Q9DB77 QCR2			0.527	2
UniProt:P62814	1	ATP6V1B2 [cytosol] (R-MMU-912598)	0.527	2
UniProt:P08228 Sod1	6	2xHC-Sod1 [mitochondrial intermembrane space] (R-MMU-3780969) SOD1 [extracellular region] (R-MMU-350705) Sod1 [mitochondrial intermembrane space] (R-MMU-3780972) 2xHC-SOD1 [mitochondrial intermembrane space] (R-MMU-3777108) SOD1 [cytosol] (R-MMU-350697) 2xHC-SOD1 [cytosol] (R-MMU-3299726)	0.527	2
UniProt:Q9DCX2	1	ATP5H [mitochondrial inner membrane] (R-MMU-50522)	0.527	2
UniProt:Q9EQH3	1	VPS35 [cytosol] (R-MMU-3247740)	0.527	2
UniProt:F6SEU4	1	SYNGAP1 [cytosol] (R-MMU-5658217)	0.527	2
UniProt:Q8R0Y6	1	phospho-ALDH1L1 [cytosol] (R-MMU-6808507)	0.527	2
UniProt:O08749	1	DLD [mitochondrial matrix] (R-MMU-69978)	0.527	2
UniProt:Q03265	1	ATP5A1 [mitochondrial matrix] (R-MMU-164575)	0.527	2
UniProt:P63242	3	EIF5A [cytosol] (R-MMU-3006308) Hyp-K50-EIF5A [cytosol] (R-MMU-3006310) Dhp-K50-EIF5A [cytosol] (R-MMU-3006309)	0.527	2
UniProt:P40142	1	TKT [cytosol] (R-MMU-71321)	0.527	2
UniProt:Q68FD5	6	CLTC-1 [cytosol] (R-MMU-350824) CLTC [lysosomal membrane] (R-MMU-2980660) CLTC-1 [trans-Golgi network membrane] (R-MMU-2130474) CLTC [endolysosome membrane] (R-MMU-8870827) CLTC [clathrin-coated endocytic vesicle membrane] (R-MMU-5138450) CLTC [plasma membrane] (R-MMU-2980668)	0.527	2
UniProt:P05064	6	ALDOA [secretory granule lumen] (R-MMU-6801469) ALDOA [platelet alpha granule lumen] (R-MMU-349738) ALDOA [ficolin-1-rich granule lumen] (R-MMU-6801521) ALDOA [extracellular region] (R-MMU-349735) ALDOA [tertiary granule lumen] (R-MMU-6801485) ALDOA [cytosol] (R-MMU-71492)	0.527	2