Gamma secretase cleaves Dner:Notch1 complex

Stable Identifier
R-MMU-2067638
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Gamma secretase cleaves Dner:Notch1 complex

In the mouse myogenic cell line C2C12, transfected with a full-length mouse Notch1 expressing vector, NICD1 produced by S3 cleavage is detectable after cells are treated with a soluble recombinant mouse Dner. Also, the effect of soluble Dner on morphology of Notch1 expressing primary glial cells isolated from mouse cerebellum is dependent on the activity of gamma-secretase.

Literature References
PubMed ID Title Journal Year
15965470 DNER acts as a neuron-specific Notch ligand during Bergmann glial development

Eiraku, M, Tohgo, A, Ono, K, Kaneko, M, Fujishima, K, Hirano, T, Kengaku, M

Nat Neurosci 2005
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