Notch1 binds Dlk1

Stable Identifier
R-MMU-2071906
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Notch1 binds Dlk1

Using a yeast two-hybrid system, mouse Notch1 and Dlk1 were found to interact and this interaction involves EGF repeats of both proteins. Co-expression of Notch1 and Dlk1 in cis results in inhibition of Notch1-mediated transcription. Notch1 and Dlk1 levels increase at confluence in mouse fibroblast cell culture, which is accompanied by a decreased transcription of the Notch1 target Hes1. Therefore, Dlk1 is implicated as a negative regulator of Notch1 signaling in cis.

Literature References
PubMed ID Title Journal Year
15652348 dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats

Baladrón, V, Ruiz-Hidalgo, MJ, Nueda, ML, Díaz-Guerra, MJM, García-Ramírez, JJ, Bonvini, E, Gubina, E, Laborda, J

Exp Cell Res 2005
Participants
Orthologous Events
Authored
Reviewed
Created