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ROCK1 [cytosol]
Stable Identifier
R-MMU-212509
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P70335
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
RHOA:GTP binds ROCK, activating it (Mus musculus)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
Semaphorin interactions (Mus musculus)
Sema4D in semaphorin signaling (Mus musculus)
Sema4D induced cell migration and growth-cone collapse (Mus musculus)
ROCK activation by RHO (Mus musculus)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,2 bind ROCKi (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Apoptotic execution phase (Mus musculus)
Apoptotic cleavage of cellular proteins (Mus musculus)
Caspase-mediated cleavage of Rock-1 (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
ROCK activation by RHO (Mus musculus)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,2 bind ROCKi (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 are activated (Mus musculus)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate ROCKs (Mus musculus)
ROCK activation by RHO (Mus musculus)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,2 bind ROCKi (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
ROCK1,ROCK2:ROCKi [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHO GTPase cycle (Mus musculus)
RHOA GTPase cycle (Mus musculus)
RHOA binds effectors at the plasma membrane (Mus musculus)
RHOA plasma membrane effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Mus musculus)
RHOA plasma membrane effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOB GTPase cycle (Mus musculus)
RHOB binds effectors at the plasma membrane (Mus musculus)
RHOB effectors (plasma membrane) [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Mus musculus)
RHOB effectors (plasma membrane) [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOBTB GTPase Cycle (Mus musculus)
RHOBTB1 GTPase cycle (Mus musculus)
RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)
RHOBTB1 interacting proteins [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Mus musculus)
RHOBTB1 interacting proteins [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOC GTPase cycle (Mus musculus)
RHOC binds effectors at the plasma membrane (Mus musculus)
RHOC effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOC:GTP:RHOC effectors [plasma membrane] (Mus musculus)
RHOC effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOH GTPase cycle (Mus musculus)
RHOH binds effectors at the plasma membrane (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RHOH:GTP:RHOH effectors [plasma membrane] (Mus musculus)
RHOH effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RND3 GTPase cycle (Mus musculus)
RND3 binds effectors (Mus musculus)
RND3 effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
RND3:GTP:RND3 effectors [plasma membrane] (Mus musculus)
RND3 effectors [cytosol] (Mus musculus)
ROCK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70335
Reference Genes
BioGPS Gene:19877
ENSEMBL:ENSMUSG00000024290
KEGG:mmu:19877
Monarch:19877
NCBI Gene:19877
UCSC:P70335
Reference Transcript
RefSeq:XM_006525725.1
RefSeq:NM_009071.2
Other Identifiers
100980_at
10457429
1423444_at
1423445_at
1441162_at
1450994_at
1460729_at
160746_at
17352621
19877
4311978
4314565
4340511
4350360
4360717
4512023
4522582
4528656
4532828
4548391
4567757
4585326
4619149
4629043
4629551
4642469
4701467
4756784
4783463
4829973
4852689
4901845
4934532
4934892
4942707
4963187
4967342
4973887
5046046
5074574
5145992
5227580
5228548
5233641
5245459
5255811
5306957
5312338
5316603
5421662
5422847
5441990
5446292
5449682
5463016
5468965
5469838
5489394
5509885
5529978
5535543
5546543
A_52_P152428
A_52_P513358
A_52_P51732
A_55_P2858140
A_65_P07569
GE1417325
GE33579
GO:0000139
GO:0000281
GO:0000910
GO:0001726
GO:0001837
GO:0002376
GO:0003013
GO:0003383
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005794
GO:0005814
GO:0005856
GO:0005886
GO:0006468
GO:0006915
GO:0007010
GO:0007155
GO:0007159
GO:0007165
GO:0007249
GO:0007266
GO:0010494
GO:0010508
GO:0010613
GO:0010628
GO:0012501
GO:0016525
GO:0016740
GO:0022614
GO:0030027
GO:0030036
GO:0030154
GO:0030334
GO:0030866
GO:0031032
GO:0031175
GO:0031267
GO:0032059
GO:0032060
GO:0032956
GO:0032970
GO:0035306
GO:0042995
GO:0043226
GO:0043410
GO:0045616
GO:0045664
GO:0046872
GO:0048598
GO:0048870
GO:0050900
GO:0050901
GO:0051451
GO:0051894
GO:0061157
GO:0070507
GO:0071559
GO:0072518
GO:0072659
GO:0090128
GO:0090521
GO:0097049
GO:0097746
GO:0098685
GO:0106310
GO:0110061
GO:0140058
GO:0140096
GO:1900223
GO:1900242
GO:1901888
GO:1902430
GO:1902992
GO:1903140
GO:1903347
GO:1905205
GO:1990776
GO:2000672
ILMN_1224513
ILMN_2418706
ILMN_2742675
U58512_s_at
aa145471_s_at
mMC008843
mMR029928
Participates
as a member of
RHOA plasma membrane effectors [cytosol] (Mus musculus)
RND3 effectors [cytosol] (Mus musculus)
RHOC effectors [cytosol] (Mus musculus)
RHOBTB1 interacting proteins [cytosol] (Mus musculus)
RHOB effectors (plasma membrane) [cytosol] (Mus musculus)
ROCK1,ROCK2 [cytosol] (Mus musculus)
as a candidate of
RHOH effectors [cytosol] (Mus musculus)
as an input of
Caspase-mediated cleavage of Rock-1 (Mus musculus)
Other forms of this molecule
ROCK1 [extracellular region]
ROCK1 [secretory granule lumen]
ROCK1(1114-1354) [cytosol]
ROCK1(1-1113) [cytosol]
Inferred From
Activated ROCK1 [cytosol]
(Homo sapiens)
ROCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033097.1
,
XP_006525788.1
ENSEMBL
ENSMUSP00000069549
,
ENSMUST00000067947
PRO
P70335
GlyGen
P70335
MGI
107927
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61588
1
RND3 [plasma membrane]
(R-MMU-9696265)
0.611
7
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