Reactome | Smad7 [cytosol]

Smad7 [cytosol]

Stable Identifier

R-MMU-2161209

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Mothers against decapentaplegic homolog 7, MAD homolog 7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
        
        USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
        
        SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Mus musculus)
        
        SMAD7:SMURF2:TGFBR1 [plasma membrane] (Mus musculus)
        
        SMAD7:SMURF2 [cytosol] (Mus musculus)
        
        Smad7 [cytosol] (Mus musculus)
        
        USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
        
        Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Mus musculus)
        
        SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Mus musculus)
        
        Smad7 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O35253 Smad7

Gene Names

Smad7, Madh7, Madh8

Chain

chain:1-426

Reference Genes

BioGPS Gene:17131 Smad7

ENSEMBL:ENSMUSG00000025880.12 Smad7

KEGG Gene (Mus musculus):17131 Smad7

Monarch:17131 Smad7

NCBI Gene:17131 Smad7

UCSC:O35253 Smad7

Reference Transcript

Other Identifiers

10456745

1423389_at

1443771_x_at

17131

17351862

4353758

4382919

4662798

4755660

4862918

5022382

5026404

5056259

5170000

5270479

5323036

5351942

5404225

5587094

92216_at

A_51_P403636

A_55_P2741400

GE33980

GO:0000122

GO:0001650

GO:0001657

GO:0002376

GO:0002725

GO:0003012

GO:0003013

GO:0003714

GO:0005515

GO:0005518

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0006351

GO:0006355

GO:0006357

GO:0007155

GO:0007179

GO:0008013

GO:0009653

GO:0010717

GO:0010801

GO:0010944

GO:0017015

GO:0022409

GO:0023052

GO:0030154

GO:0030279

GO:0030512

GO:0030514

GO:0031397

GO:0031503

GO:0031625

GO:0032926

GO:0032991

GO:0033137

GO:0034330

GO:0034333

GO:0034616

GO:0034713

GO:0035556

GO:0036211

GO:0043226

GO:0046872

GO:0048844

GO:0048856

GO:0050821

GO:0055010

GO:0055117

GO:0060090

GO:0060373

GO:0060392

GO:0060395

GO:0060412

GO:0070411

GO:0070697

GO:0071144

GO:0071560

GO:0098772

GO:0140110

GO:0140416

GO:1902731

GO:1903043

GO:1990756

GO:1990830

GO:2000317

GO:2000320

ILMN_2759660

mMC009969

Participates

as a component of

as a member of

I-SMAD [cytosol] (Mus musculus)

as an input of

as an output of

PP1CC dephosphorylates TGFBR1 (Homo sapiens)

Other forms of this molecule

Smad7 [nucleoplasm]

Inferred From

SMAD7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006525766.1, NP_001036125.1

Ensembl

ENSMUST00000026999, ENSMUSP00000026999, ENSMUSG00000025880

PRO

O35253

MGI

1100518

PDB

7CD1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.524	6