Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-T,Y-MAPK8 [nucleoplasm]
Stable Identifier
R-MMU-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q91Y86
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Innate Immune System (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated human JNKs migrate to nucleoplasm (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
Activation of the AP-1 family of transcription factors (Mus musculus)
Activated JNKs phosphorylate c-JUN (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Phosphorylated MAPKs phosphorylate ATF-2 (Mus musculus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Mus musculus)
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)
phospho-p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q91Y86 Mapk8
Gene Names
Mapk8, Jnk1, Prkm8
Chain
chain:1-384
Reference Genes
BioGPS Gene:26419 Mapk8
ENSEMBL:ENSMUSG00000021936.15 Mapk8
KEGG Gene (Mus musculus):26419 Mapk8
Monarch:26419 Mapk8
NCBI Gene:26419 Mapk8
UCSC:Q91Y86 Mapk8
Reference Transcript
RefSeq:NM_016700.4 Mapk8
Other Identifiers
100391_at
104047_at
10418879
136056_at
138042_at
1420931_at
1420932_at
1440856_at
1446014_at
1457936_at
17304976
26419
4309361
4410844
4455656
4475670
4497613
4539375
4564749
4609207
4653215
4664069
4938167
4983298
5085045
5088830
5226170
5241414
5264746
5290571
5341029
5391184
5392306
5456276
5501351
5529883
5539600
5546991
5567435
5592214
A_51_P357182
A_52_P274352
A_52_P558382
A_55_P1973299
A_55_P2020410
A_55_P2506650
GE36985
GO:0000165
GO:0000166
GO:0001503
GO:0001764
GO:0002052
GO:0002102
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0006260
GO:0006351
GO:0006355
GO:0006468
GO:0006979
GO:0007010
GO:0007254
GO:0008092
GO:0009411
GO:0009612
GO:0010468
GO:0010628
GO:0010666
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019894
GO:0019899
GO:0019903
GO:0023052
GO:0030154
GO:0030163
GO:0030335
GO:0030424
GO:0031116
GO:0031175
GO:0031398
GO:0031982
GO:0032436
GO:0032839
GO:0032880
GO:0034198
GO:0034352
GO:0034599
GO:0034614
GO:0035033
GO:0036211
GO:0042542
GO:0042752
GO:0042826
GO:0043005
GO:0043065
GO:0043066
GO:0043204
GO:0043226
GO:0043227
GO:0043229
GO:0043525
GO:0045202
GO:0045664
GO:0045740
GO:0046605
GO:0046686
GO:0048263
GO:0048511
GO:0048813
GO:0048856
GO:0048870
GO:0050804
GO:0051247
GO:0051403
GO:0060395
GO:0061833
GO:0065003
GO:0070301
GO:0071222
GO:0071276
GO:0071732
GO:0071803
GO:0090650
GO:0097050
GO:0097150
GO:0097190
GO:0097300
GO:0097441
GO:0098685
GO:0098772
GO:0106310
GO:0120283
GO:0140096
GO:1900227
GO:1904809
GO:2000017
GO:2001224
GO:2001235
ILMN_2456617
ILMN_2760609
mMC002169
mMR026268
Participates
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Mus musculus)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Mus musculus)
Other forms of this molecule
Phospho-Jnk1 [cytosol]
Jnk1 [cytosol]
MAPK8 [cytosol]
phospho-p-T,Y-MAPK8 [cytosol]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_057909.1
Ensembl
ENSMUST00000111945
,
ENSMUSP00000107576
,
ENSMUSG00000021936
ZINC target
Q91Y86
PRO
Q91Y86
ZINC - Predictions - Purchasable
MK08_MOUSE
MGI
1346861
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05627 Jun
5
p-S63,S73-Jun [cytosol]
(R-MMU-8868678)
Jun [cytosol]
(R-MMU-8868685)
Jun [nucleoplasm]
(R-MMU-3261183)
phospho-Jun [nucleoplasm]
(R-MMU-450237)
Jun [nucleoplasm]
(R-MMU-450250)
0.623
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text