Reactome: A Curated Pathway Database

Adam10 cleaves Notch2

Stable Identifier
R-MMU-2193065
Type
Reaction
Species
Mus musculus
Compartment
Summation

Adam10 knockout mice have impaired development of the marginal zone B-cell lineage, known to be dependent on Notch2 signaling. Notch2 activation is also impaired in Adam10 knockout mice, supporting the role of Adam10 in Notch2 proteolytic processing and activation upon ligand binding (Gibb et al. 2010).

Literature References
Participants
This entity is regulated by:
Title Physical Entity Activity
metalloendopeptidase activity of Adam10 [plasma membrane] Adam10 [plasma membrane] metalloendopeptidase activity (0004222)
Orthologous Events