Adam10 cleaves Notch2

Stable Identifier
R-MMU-2193065
Type
Reaction
Species
Mus musculus
Compartment
Summation

Adam10 knockout mice have impaired development of the marginal zone B-cell lineage, known to be dependent on Notch2 signaling. Notch2 activation is also impaired in Adam10 knockout mice, supporting the role of Adam10 in Notch2 proteolytic processing and activation upon ligand binding (Gibb et al. 2010).

Literature References
PubMed ID Title Journal Year
20156974 ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

Gibb, DR, El Shikh, M, Kang, DJ, Rowe, WJ, El Sayed, R, Cichy, J, Yagita, H, Tew, JG, Dempsey, PJ, Crawford, HC, Conrad, DH

J Exp Med 2010
Participants
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of Adam10 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed