Reactome | Dnm1 [cytosol]

Dnm1 [cytosol]

Stable Identifier

R-MMU-2213182

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DNM1, P39053

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        DNM:GDP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        DNM:GTP [cytosol] (Mus musculus)
        
        Dynamin [cytosol] (Mus musculus)
        
        Dnm1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P39053

Gene Names

Dnm1

Reference Genes

BioGPS Gene:13429 Dnm1

ENSEMBL:ENSMUSG00000026825

KEGG:mmu:13429 Dnm1

Monarch:13429 Dnm1

NCBI Gene:13429 Dnm1

UCSC:P39053 Dnm1

Reference Transcript

Other Identifiers

103030_at

103031_g_at

10481592

114700_at

133140_at

13429

1427754_a_at

1460365_a_at

17383858

4322861

4358132

4410321

4421066

4455000

4495299

4504615

4509959

4533489

4534177

4566222

4605461

4616756

4667832

4715655

4921971

4939463

4945996

4951987

4993687

5022840

5137263

5219579

5255766

5274876

5298994

5304019

5313522

5313714

5340607

5352752

5372697

5420205

5444240

5464909

5471860

5515941

5523282

5525735

5540477

5560456

5578054

5580864

A_51_P219868

A_55_P2079167

A_55_P2079175

GE33022

GO:0000166

GO:0001917

GO:0003924

GO:0005515

GO:0005525

GO:0005546

GO:0005547

GO:0005737

GO:0005874

GO:0005886

GO:0005905

GO:0006897

GO:0006898

GO:0007032

GO:0008017

GO:0008092

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0019003

GO:0019901

GO:0030117

GO:0030139

GO:0031410

GO:0042583

GO:0042802

GO:0042803

GO:0042995

GO:0043209

GO:0045202

GO:0048488

GO:0050804

GO:0051260

GO:0051289

GO:0065003

GO:0097494

GO:0098684

GO:0098793

GO:0098835

GO:0098978

GO:0099049

GO:0099050

ILMN_1214326

ILMN_1224127

ILMN_2658618

ILMN_2722984

l31397_s_at

mMC019279

Participates

as a candidate of

Dynamin [cytosol] (Mus musculus)

Other forms of this molecule

Dnm1 [lysosomal membrane]

Dnm1 [plasma membrane]

Inferred From

DNM1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_034195.2, NP_001288666.1, XP_006497723.2, XP_006497724.2, XP_006497722.2, XP_006497721.2, XP_017170817.1, XP_006497718.2

ENSEMBL

ENSMUSP00000077461, ENSMUSG00000026825, ENSMUST00000091089, ENSMUSP00000088618, ENSMUSP00000108992, ENSMUST00000202578, ENSMUST00000113350, ENSMUST00000113365, ENSMUST00000078352, ENSMUSP00000122679, ENSMUSP00000108979, ENSMUSP00000143955, ENSMUSP00000108977, ENSMUST00000139624, ENSMUST00000113352

IntEnz

3.6.5.5

PRO

P39053

GlyGen

P39053

MGI

107384

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.669	3
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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