RalA Exchanges GDP for GTP

Stable Identifier
R-MMU-2255339
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
RalA Exchanges GDP for GTP

RalA releases GDP and binds GTP (inferred from the simian RalA in Frech et al. 1990). The reaction is enhanced by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which activate the intrinsic GTPase activity of RalA (Chen et al. 2011).

Literature References
PubMed ID Title Journal Year
2108160 Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli

Frech, M, Schlichting, I, Wittinghofer, A, Chardin, P

J. Biol. Chem. 1990
21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, XW, Leto, D, Xiong, T, Yu, G, Cheng, A, Decker, S, Saltiel, AR

Mol Biol Cell 2011
Participants
Orthologous Events
Authored
Reviewed
Created
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