Interaction of DAP12 and NKG2D

Stable Identifier
R-MMU-2326808
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of DAP12 and NKG2D
NKG2D is a member of the NKG2 family of C-type lectin-like surface receptors. It is a homodimeric activating receptor expressed on natural killer (NK) cells, gamma/delta T-cells and CD8+ alpha/beta T-cells. NKG2D can mediate NK activation and cytotoxicity. NKG2D interacts with the stress-induced class I like molecules MICA, MICB and ULBPs expressed on target cells. Interaction of NKG2D and NKG2D ligands leads to NK cell activation (Cosman et al. 2001, Steinle et al. 2001, Long. 2002). In mice there are two alternatively spliced isoforms of NKG2D, designated NKG2D-S and NKG2D-L. DAP12 interacts with NKG2D-S, but not NKG2D-L, whereas the DAP10 adapter associates with both NKG2D-S and NKG2D-L (Gilfillan et al. 2002, Diefenbach et al. 2002). Humans only express an NKG2D-L isoform and exclusively associate with DAP10, and not DAP12 A Structural basis for the association of DAP12 with mouse, but not human, NKG2D (Rosen et al. 2004).
Literature References
PubMed ID Title Journal Year
11491531 Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family

Steinle, A, Groh, V, Lanier, LL, Morris, DL, Spies, T, Li, P, Strong, RK

Immunogenetics 0
12426564 NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

Yokoyama, WM, Colonna, M, Ho, EL, Gilfillan, S, Cella, M

Nat Immunol 2002
11239445 ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

Armitage, R, Chalupny, NJ, Sutherland, CL, Kubin, M, Chin, W, Müllberg, J, Fanslow, W, Cosman, D

Immunity 2001
12426565 Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

Raulet, DH, Vivier, E, Diefenbach, A, Lucas, M, Hsia, JK, Jamieson, AM, Tomasello, E

Nat Immunol 2002
Participants
Input
Output
Orthologous Events
Interaction of DAP12 and NKG2D (Homo sapiens)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-06-19)
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