Me2Se is methylated to Me3Se+ by Inmt

Stable Identifier
R-MMU-2408549
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Me2Se is methylated to Me3Se+ by Inmt
In mouse cytosol, indolethylamine N-methyltransferase (Inmt) is involved in the methylation of dimethyl selenide (Me2Se) into trimethylselenonium (Me3Se+) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy) (Mozier et al. 1988).
Literature References
PubMed ID Title Journal Year
3350800 S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism

Mozier, NM, McConnell, KP, Hoffman, JL

J. Biol. Chem. 1988
Participants
Input
Output
Catalyst Activity

dimethyl selenide methyltransferase activity of Inmt [cytosol]

Physical Entity
Inmt [cytosol] (Mus musculus)
Activity
dimethyl selenide methyltransferase activity (GO:0098615)
Orthologous Events
Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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