Extracellular CR:atREs are transported to cytosol by Ldlr

Stable Identifier
R-MMU-2425403
Type
Reaction
Species
Mus musculus
Compartment
Summation

Chylomicron remnants (CRs) are "sieved" when they arrive at the liver by size, the appropriate sized remnants passing through the space of Disse. Once inside, CRs containing all-trans-retinyl esters (atREs) can be directly and rapidly taken up by liver parenchymal cells via the low-density lipoprotein receptor (Ldlr) using apolipoprotein E (Apoe) as a ligand. This process has been demonstrated in mice uptake studies (Yu et al. 2000).

Participants
Catalyst Activity
Catalyst Activity
Title
low-density lipoprotein receptor activity of Ldlr [plasma membrane]
Physical Entity
Activity
Orthologous Events