p-12Y-Jak2 [cytosol]

Stable Identifier
R-MMU-2586515
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Tyrosine-protein kinase JAK2 ecNumber2.7.10.2/ecNumber, JAK2_MOUSE, Jak2
Literature References
PubMed ID Title Journal Year
15530433 Determination of the transphosphorylation sites of Jak2 kinase

Matsuda, T, Feng, J, Witthuhn, BA, Sekine, Y, Ihle, JN

Biochem Biophys Res Commun 2004
9111318 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

Feng, J, Witthuhn, BA, Matsuda, T, Kohlhuber, F, Kerr, IM, Ihle, JN

Mol Cell Biol 1997
15065871 Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state

Chatti, K, Farrar, WL, Duhé, RJ

Biochemistry 2004
15143187 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

Argetsinger, LS, Kouadio, JL, Steen, H, Stensballe, A, Jensen, ON, Carter-Su, C

Mol Cell Biol 2004
19364823 Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling

Robertson, SA, Koleva, RI, Argetsinger, LS, Carter-Su, C, Marto, JA, Feener, EP, Myers, MG

Mol. Cell. Biol. 2009
15121872 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

Kurzer, JH, Argetsinger, LS, Zhou, YJ, Kouadio, JL, O'Shea, JJ, Carter-Su, C

Mol Cell Biol 2004
17024180 Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2

Funakoshi-Tago, M, Pelletier, S, Matsuda, T, Parganas, E, Ihle, JN

EMBO J. 2006
21726629 Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation

Sayyah, J, Gnanasambandan, K, Kamarajugadda, S, Tsuda, S, Caldwell-Busby, J, Sayeski, PP

Cell. Signal. 2011
17565041 SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms

Li, Z, Zhou, Y, Carter-Su, C, Myers, MG, Rui, L

Mol. Endocrinol. 2007
20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Argetsinger, LS, Stuckey, JA, Robertson, SA, Koleva, RI, Cline, JM, Marto, JA, Myers MG, Jr, Carter-Su, C

Mol Endocrinol 2010
External Reference Information
External Reference
UniProt:Q62120 Jak2
Gene Names
Jak2
Chain
chain:1-1129
Reference Genes
BioGPS Gene:16452 Jak2
dbSNP Gene:16452 Jak2
KEGG Gene (Mus musculus):16452 Jak2
Monarch:16452 Jak2
NCBI Gene:16452 Jak2
Reference Transcript
Participant Of
hasComponent
Other forms of this molecule
phospho-p-Y1007-JAK2 [cytosol]
JAK2 [cytosol]
Jak2 [cytosol]
phospho-p-12Y-JAK2 [cytosol]
p-Y1007-Jak2 [cytosol]
JAK2 [endosome lumen]
phospho-p-Y813-JAK2 [cytosol]
phospho-p-Y1007,Y1008-JAK2 [cytosol]
phospho-p-JAK2 [cytosol]
p-Jak2 [cytosol]
Inferred To
p-12Y-JAK2 [cytosol] (Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 868
Coordinate
868
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 966
Coordinate
966
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 972
Coordinate
972
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1008
Coordinate
1008
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 813
Coordinate
813
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 119
Coordinate
119
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 221
Coordinate
221
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 372
Coordinate
372
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 373
Coordinate
373
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 570
Coordinate
570
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 637
Coordinate
637
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1007
Coordinate
1007
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
ZINC - Predictions - Purchasable
PDB
Interactors (7)