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phospho-Jak2 [cytosol]
Stable Identifier
R-MMU-2586516
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-12Y-JAK2, Q62120
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to EPOR [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
Erythropoietin activates RAS (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
phospho-Jak2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62120 Jak2
Gene Names
Jak2
Chain
chain:1-1129
Reference Genes
BioGPS Gene:16452 Jak2
KEGG Gene (Mus musculus):16452 Jak2
Monarch:16452 Jak2
NCBI Gene:16452 Jak2
Reference Transcript
RefSeq:NM_008413.3 Jak2
RefSeq:NM_001048177.2 Jak2
Participant Of
hasComponent
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane]
hasCandidate
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]
Other forms of this molecule
phospho-Jak2 [cytosol]
Jak2 [cytosol]
Jak2 [cytosol]
p-12Y-Jak2 [cytosol]
p-Y1007-Jak2 [cytosol]
Jak2 [endosome lumen]
phospho-Jak2 [cytosol]
phospho-Jak2 [cytosol]
phospho-Jak2 [cytosol]
p-Jak2 [cytosol]
Inferred From
p-12Y-JAK2 [cytosol] (Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 868
Coordinate
868
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 966
Coordinate
966
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 972
Coordinate
972
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1008
Coordinate
1008
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 813
Coordinate
813
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 119
Coordinate
119
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 221
Coordinate
221
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 372
Coordinate
372
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 373
Coordinate
373
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 570
Coordinate
570
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 637
Coordinate
637
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1007
Coordinate
1007
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001041642.1
,
NP_032439.2
ZINC - World Drugs
JAK2_MOUSE
ZINC - FDA approved
JAK2_MOUSE
ZINC - Substances
JAK2_MOUSE
ZINC target
Q62120
PRO
Q62120
MGI
96629
ZINC - Predictions - Purchasable
JAK2_MOUSE
PDB
2HDX
,
4GL9
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q91ZM2 Sh2b1
2
Sh2b1 [cytosol]
(R-MMU-1675482)
Sh2b1 [cytosol]
(R-MMU-2671856)
0.667
3
UniProt:P46527 CDKN1B
8
CDKN1B [nucleoplasm]
(R-HSA-182563)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.626
7
UniProt:P14753 Epor
3
p-8Y-Epor [plasma membrane]
(R-MMU-9006275)
EpoR [plasma membrane]
(R-MMU-206154)
phospho-Epor [plasma membrane]
(R-MMU-9006274)
0.589
4
UniProt:P48356 Lepr
0.524
3
UniProt:Q5VWK5 IL23R
2
IL23R [plasma membrane]
(R-HSA-447156)
p-Y-IL23R [plasma membrane]
(R-HSA-8950616)
0.499
2
UniProt:O35716 Socs1
2
Socs1 [cytosol]
(R-MMU-204910)
Socs1 [cytosol]
(R-MMU-912674)
0.482
2
UniProt:P10686 Plcg1
8
phospho-Plcg1 [plasma membrane]
(R-RNO-1169084)
p-4Y-Plcg1 [plasma membrane]
(R-RNO-9034825)
Plcg1 [plasma membrane]
(R-RNO-182093)
Plcg1 [plasma membrane]
(R-RNO-167682)
p-Plcg1 [plasma membrane]
(R-RNO-182042)
Plcg1 [cytosol]
(R-RNO-202320)
phospho-Plcg1 [cytosol]
(R-RNO-202357)
phospho-Plcg1 [plasma membrane]
(R-RNO-167679)
0.463
3
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