Leptin Binds Leptin Receptor

Stable Identifier
R-MMU-2586558
Type
Reaction
Species
Mus musculus
Compartment
Synonyms
Lep Binds Lepr:Jak2
General
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Leptin Binds Leptin Receptor

Leptin binds the Leptin receptor, a transmembrane receptor that is constitutively associated with the Jak2 kinase at the cytoplasmic face.

Literature References
PubMed ID Title Journal Year
8710878 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

Baumann, H, Morella, KK, White, DW, Dembski, M, Bailon, PS, Kim, H, Lai, CF, Tartaglia, LA

Proc. Natl. Acad. Sci. U.S.A. 1996
9218470 Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

Devos, R, Guisez, Y, Van der Heyden, J, White, DW, Kalai, M, Fountoulakis, M, Plaetinck, G

J. Biol. Chem. 1997
15051545 BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry

MistrĂ­k, P, Moreau, F, Allen, JM

Anal. Biochem. 2004
8548812 Identification and expression cloning of a leptin receptor, OB-R

Tartaglia, LA, Dembski, M, Weng, X, Deng, N, Culpepper, J, Devos, R, Richards, GJ, Campfield, LA, Clark, FT, Deeds, J, Muir, C, Sanker, S, Moriarty, A, Moore, KJ, Smutko, JS, Mays, GG, Wool, EA, Monroe, CA, Tepper, RI

Cell 1995
9092791 The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

Ghilardi, N, Skoda, RC

Mol. Endocrinol. 1997
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Orthologous Events
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