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Hspa8 [cytosol]
Stable Identifier
R-MMU-264476
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
HSPA8, P63017
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)
HSP70s:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
HSP70s:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Hikeshi binds HSP70s:ATP (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Hikeshi:HSP70s:ATP [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)
Hikeshi:HSP70s:ATP [cytosol] (Mus musculus)
HSP70s:ATP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Mus musculus)
ATP binding to HSP90 triggers conformation change (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
ATP hydrolysis by HSP70 (Mus musculus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP70 binds to HSP40:nascent protein (Mus musculus)
HSP40:HSP70:ATP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)
HSP40:HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Mus musculus)
HSP70:ATP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Mus musculus)
HSP70:ADP [cytosol] (Mus musculus)
HSP70 proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Mus musculus)
AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
AUF1 binds translation and heat shock proteins (Mus musculus)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
clathrin:HSPA8:ADP [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
trans-Golgi Network Vesicle Budding (Mus musculus)
Golgi Associated Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Derived Vesicle Uncoating (Mus musculus)
HSC70:Auxillin Complex [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
Lysosome Vesicle Biogenesis (Mus musculus)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)
HSC70:Auxillin Complex [cytosol] (Mus musculus)
Hspa8 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P63017 Hspa8
Gene Names
Hspa8, Hsc70, Hsc73
Chain
initiator methionine:1, chain:2-646
Reference Genes
BioGPS Gene:15481 Hspa8
ENSEMBL:ENSMUSG00000015656 Hspa8
KEGG Gene (Mus musculus):15481 Hspa8
Monarch:15481 Hspa8
NCBI Gene:15481 Hspa8
UCSC:P63017 Hspa8
Reference Transcript
RefSeq:NM_031165.4 Hspa8
Other Identifiers
10368025
10528021
10584572
1420622_a_at
1420623_x_at
1455789_x_at
15481
17516365
4319466
4375983
4551525
4631211
4725668
4763740
4773098
4856253
4870419
4872942
4875329
4957859
4960695
4980268
5013139
5070125
5146835
5175250
5214873
5256594
5388514
5429764
5526135
96564_at
A_51_P170371
A_52_P12877
A_55_P2080603
ILMN_1246458
ILMN_1249586
ILMN_2772022
ILMN_2918479
Msa.23647.0_f_at
Msa.34101.0_f_at
Msa.778.0_f_at
mMC025232
u73744_f_at
Participates
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Mus musculus)
HSC70:Auxillin Complex [cytosol] (Mus musculus)
HSPA8:ADP [cytosol] (Mus musculus)
HSPA8:ATP [cytosol] (Mus musculus)
as an input of
AUF1 binds translation and heat shock proteins (Mus musculus)
as a member of
HSP70 proteins [cytosol] (Mus musculus)
Other forms of this molecule
Hspa8 [nucleoplasm]
Hspa8 [nucleoplasm]
Hspa8 [ficolin-1-rich granule lumen]
Hspa8 [extracellular region]
Hspa8 [secretory granule lumen]
Hspa8 [plasma membrane]
Hspa8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Hspa8 [late endosome lumen]
Hspa8 [cytosol]
Inferred From
HSPA8 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_112442.2
Target Pathogen
5b354852be737e166372e73a
Ensembl
ENSMUSP00000015800
,
ENSMUST00000015800
,
ENSMUSG00000015656
PRO
P63017
MGI
105384
PDB
3CQX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O41974 O41974
0.576
3
UniProt:P63101 Ywhaz
3
Ywhaz [nucleoplasm]
(R-MMU-450469)
Ywhaz [cytosol]
(R-MMU-206099)
14-3-3zeta [cytosol]
(R-MMU-206177)
0.527
2
UniProt:Q08460 Kcnma1
2
Kcnma1 [plasma membrane]
(R-MMU-418462)
Kcnma1 [plasma membrane]
(R-MMU-9667781)
0.527
2
UniProt:P43883 Plin2
3
p-Plin2 [cytosol]
(R-MMU-9613673)
Plin2 [lipid droplet]
(R-MMU-9613518)
p-Plin2 [lipid droplet]
(R-MMU-9613540)
0.524
3
UniProt:O88447
1
Klc1 [cytosol]
(R-MMU-983284)
0.499
3
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