Phosphorylated Lepr Binds Shp2

Stable Identifier
R-MMU-2671739
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Lepr Binds Shp2

Shp2 interacts with phosphotyrosine-985 of the phosphorylated Leptin receptor Lepr.

Literature References
PubMed ID Title Journal Year
11085989 Divergent roles of SHP-2 in ERK activation by leptin receptors

Bjørbaek, C, Buchholz, RM, Davis, SM, Bates, SH, Pierroz, DD, Gu, H, Neel, BG, Myers, MG, Flier, JS

J. Biol. Chem. 2001
10449753 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C, Friedman, JM

Proc. Natl. Acad. Sci. U.S.A. 1999
10799542 Activation of downstream signals by the long form of the leptin receptor

Banks, AS, Davis, SM, Bates, SH, Myers, MG

J. Biol. Chem. 2000
Participants
Input
Output
Orthologous Events
Phosphorylated LEPR Binds SHP2 (PTPN11) (Homo sapiens)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-24)