Jak2 Phosphorylates Irs1/2 in Response to Leptin

Stable Identifier
R-MMU-2671830
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Jak2 Phosphorylates Irs1/2 in Response to Leptin

Jak2 in the Lep:Lepr:Jak2:Sh2b1:Irs1/2 complex phosphorylates Irs1/2. Phosphorylated Irs1/2 activates PI3K, AKT, and mTOR signaling pathways.

Literature References
PubMed ID Title Journal Year
9389430 Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

Kellerer, M, Koch, M, Metzinger, E, Mushack, J, Capp, E, Häring, HU

Diabetologia 1997
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Sh2b1:Irs1,2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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