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Phosphorylated Lep:Lepr:Jak2:Sh2b1 Binds Irs1/2
Stable Identifier
R-MMU-2671841
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
General
SBML
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BioPAX
Level 2
Level 3
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SBGN
Irs1/2 binds Sh2b1 within the Lep:Lepr:Jak2:Sh2b1 complex. This brings Irs1/2 into proximity with the Jak2 kinase.
Literature References
PubMed ID
Title
Journal
Year
15316008
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
Duan, C
,
Li, M
,
Rui, L
J Biol Chem
2004
10377387
Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
Carter-Su, C
,
Rui, L
Proc. Natl. Acad. Sci. U.S.A.
1999
Participants
Input
x 2
Irs1,2 [cytosol]
(Mus musculus)
Lep:p-Lepr:p-Jak2:Sh2b1 [plasma membrane]
(Mus musculus)
Output
Lep:p-Lepr:p-Jak2:Sh2b1:Irs1,2 [plasma membrane]
(Mus musculus)
Orthologous Events
Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
Authored
May, B (2012-11-24)
Reviewed
Scherer, T (2013-08-31)
Gonzalez-Perez, RR (2013-10-26)
Created
May, B (2012-11-26)
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