Jak2 Phosphorylates Stat5 in Response to Leptin

Stable Identifier
R-MMU-2671843
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Jak2 Phosphorylates Stat5 in Response to Leptin

Phosphorylated Jak2 phosphorylates Stat5 (at tyrosine-694 of Stat5a) while Stat5 is bound to Lepr.

Literature References
PubMed ID Title Journal Year
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P, Zeidler, J, Bamberg-Lemper, S, Knobelspies, H, Lavens, D, Tavernier, J, Joost, HG, Becker, W

FEBS J. 2005
17726024 The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms

Gong, Y, Ishida-Takahashi, R, Villanueva, EC, Fingar, DC, M├╝nzberg, H, Myers, MG

J. Biol. Chem. 2007
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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