Phosphorylated Stat3 Dissociates from Leptin Receptor

Stable Identifier
R-MMU-2671877
Type
Reaction [dissociation]
Species
Mus musculus
Compartment
plasma membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Stat3 Dissociates from Leptin Receptor

Phosphorylated Stat3 dissociates from Lepr, dimerizes, and translocates to the nucleus.

Literature References
PubMed ID Title Journal Year
8782827 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

Vaisse, C, Halaas, JL, Horvath, CM, Darnell, JE, Stoffel, M, Friedman, JM

Nat. Genet. 1996
9003804 Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, K, Narazaki, M, Taga, T

FEBS Lett. 1997
10799542 Activation of downstream signals by the long form of the leptin receptor

Banks, AS, Davis, SM, Bates, SH, Myers, MG

J. Biol. Chem. 2000
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P, Zeidler, J, Bamberg-Lemper, S, Knobelspies, H, Lavens, D, Tavernier, J, Joost, HG, Becker, W

FEBS J. 2005
Participants
Input
Output
Orthologous Events
Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)
Authored
May, B  (2012-11-24)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)