Phosphorylated Lepr Binds Socs3

Stable Identifier
R-MMU-2672295
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Lepr Binds Socs3

Socs3 binds phosphotyrosine-985 (Bjorbaek et al. 2000, De Souza et al. 2002, Knobelspies et al. 2010) and phosphotyrosine-1077 (Knobelspies et al. 2010) of Lepr. Socs3 acts to downregulate leptin signaling.

Literature References
PubMed ID Title Journal Year
12119038 SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

De Souza, D, Fabri, LJ, Nash, A, Hilton, DJ, Nicola, NA, Baca, M

Biochemistry 2002
11018044 SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

Bjorbak, C, Lavery, HJ, Bates, SH, Olson, RK, Davis, SM, Flier, JS, Myers, MG

J. Biol. Chem. 2000
20059770 Mechanism of attenuation of leptin signaling under chronic ligand stimulation

Knobelspies, H, Zeidler, J, Hekerman, P, Bamberg-Lemper, S, Becker, W

BMC Biochem. 2010
Participants
Input
Output
Orthologous Events
Phosphorylated LEPR Binds SOCS3 (Homo sapiens)
Authored
May, B  (2012-11-27)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-27)
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