Phosphorylated Lepr Binds Socs3

Stable Identifier
R-MMU-2672295
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Phosphorylated Lepr Binds Socs3
Socs3 binds phosphotyrosine-985 (Bjorbaek et al. 2000, De Souza et al. 2002, Knobelspies et al. 2010) and phosphotyrosine-1077 (Knobelspies et al. 2010) of Lepr. Socs3 acts to downregulate leptin signaling.
Literature References
PubMed ID Title Journal Year
11018044 SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

Lavery, HJ, Olson, RK, Myers, MG, Flier, JS, Bates, SH, Bjorbak, C, Davis, SM

J. Biol. Chem. 2000
12119038 SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

De Souza, D, Nash, A, Nicola, NA, Hilton, DJ, Baca, M, Fabri, LJ

Biochemistry 2002
20059770 Mechanism of attenuation of leptin signaling under chronic ligand stimulation

Bamberg-Lemper, S, Knobelspies, H, Hekerman, P, Becker, W, Zeidler, J

BMC Biochem. 2010
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