Socs3 binds phosphotyrosine-985 (Bjorbaek et al. 2000, De Souza et al. 2002, Knobelspies et al. 2010) and phosphotyrosine-1077 (Knobelspies et al. 2010) of Lepr. Socs3 acts to downregulate leptin signaling.
De Souza, D, Fabri, LJ, Nash, A, Hilton, DJ, Nicola, NA, Baca, M
Bjorbak, C, Lavery, HJ, Bates, SH, Olson, RK, Davis, SM, Flier, JS, Myers, MG
Knobelspies, H, Zeidler, J, Hekerman, P, Bamberg-Lemper, S, Becker, W
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