Clcn3 exchanges Cl- for H+

Stable Identifier
R-MMU-2730951
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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The murine H+/Cl- exchange transporter Clcn3 mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes (Borsani et al. 1995, Stobrawa et al. 2001, Hara-Chikuma et al. 2005).

Literature References
PubMed ID Title Journal Year
15504734 ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

Hara-Chikuma, M, Yang, B, Sonawane, ND, Sasaki, S, Uchida, S, Verkman, AS

J. Biol. Chem. 2005
11182090 Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Stobrawa, SM, Breiderhoff, T, Takamori, S, Engel, D, Schweizer, M, Zdebik, AA, Bösl, MR, Ruether, K, Jahn, H, Draguhn, A, Jahn, R, Jentsch, TJ

Neuron 2001
7665160 Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

Borsani, G, Rugarli, EI, Taglialatela, M, Wong, C, Ballabio, A

Genomics 1995
Participants
Catalyst Activity
Catalyst Activity
Title
antiporter activity of Clcn3 [late endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created