Reactome | Itgb3bp [cytosol]

Itgb3bp [cytosol]

Stable Identifier

R-MMU-3006405

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ITGB3BP, Q9CQ82

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        CCAN network [cytosol] (Mus musculus)
        
        CENP-O complex [cytosol] (Mus musculus)
        
        Itgb3bp [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQ82

Gene Names

Itgb3bp

Reference Genes

BioGPS Gene:67733 Itgb3bp

ENSEMBL:ENSMUSG00000028549

ENSEMBL:ENSMUSG00000028549.18 Itgb3bp

KEGG Gene (Mus musculus):67733 Itgb3bp

Monarch:67733 Itgb3bp

NCBI Gene:67733 Itgb3bp

UCSC:Q9CQ82 Itgb3bp

Reference Transcript

RefSeq:NM_026348.3 Itgb3bp

Other Identifiers

10514650

1420665_at

1449953_at

1456097_a_at

163870_at

17427563

4460087

4489824

4559223

4582758

4659425

4728208

5054894

5121320

5225383

5250342

5276398

5313700

5448678

5479001

67733

A_51_P257371

A_52_P678909

A_55_P2098539

A_55_P2153872

GE41205

GO:0000775

GO:0000776

GO:0000939

GO:0003674

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006351

GO:0006355

GO:0006915

GO:0007049

GO:0007059

GO:0012501

GO:0034080

GO:0043226

GO:0050679

GO:0051301

GO:0065003

GO:1904036

ILMN_1213858

ILMN_2746021

mMC003773

Participates

as an input of

TRAF6 polyubiquitinates NRIF (Mus musculus)

as an output of

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)

as a component of

Other forms of this molecule

Itgb3bp [nucleoplasm]

Inferred From

ITGB3BP [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_080624.1

Ensembl

ENSMUSP00000117153, ENSMUSG00000028549, ENSMUST00000146258

PRO

Q9CQ82

MGI

1914983

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