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TP53 Tetramer [nucleoplasm]
Stable Identifier
R-MMU-3209194
Type
Complex
Species
Mus musculus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G1/S DNA Damage Checkpoints (Mus musculus)
p53-Dependent G1/S DNA damage checkpoint (Mus musculus)
p53-Dependent G1 DNA Damage Response (Mus musculus)
Stabilization of p53 (Mus musculus)
ATM phosphorylates TP53 at S15 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
MDM2 binds TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
MDM2 ubiquitinates TP53 (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
ATM phosphorylates TP53 at S15 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Oncogene Induced Senescence (Mus musculus)
MDM2 ubiquitinates TP53 (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
MAPKAPK5 phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
MDM2 ubiquitinates TP53 (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
ATM phosphorylates TP53 at S15 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Association with Co-factors (Mus musculus)
BANP binds TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53:BANP [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Regulation of TP53 Activity through Methylation (Mus musculus)
EHMT1:EHMT2 dimethylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Regulation of TP53 Activity through Phosphorylation (Mus musculus)
AMPK phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
ATM phosphorylates TP53 at S15 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
AURKA phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
CDK2 phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
CDK5 phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
MAPKAPK5 phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
NUAK1 phosphorylates TP53 (Mus musculus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TAF1 phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 binds HIPK1 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 binds STK11 and NUAK1 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53RK phosphorylates TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
MDM2 binds TP53 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
MDM2 ubiquitinates TP53 (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Regulation of TP53 Expression (Mus musculus)
TP53 forms homotetramers (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX3 (Mus musculus)
RUNX3 regulates CDKN1A transcription (Mus musculus)
RUNX3 binds TP53 (Mus musculus)
RUNX3:TP53 tetramer [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
PKR-mediated signaling (Mus musculus)
p-PKR dimer phosphorylates TP53 tetramer (Mus musculus)
TP53 Tetramer [nucleoplasm] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 4
TP53 [nucleoplasm]
(Mus musculus)
Participates
as an input of
RUNX3 binds TP53 (Mus musculus)
EHMT1:EHMT2 dimethylates TP53 (Mus musculus)
BANP binds TP53 (Mus musculus)
p-PKR dimer phosphorylates TP53 tetramer (Mus musculus)
AURKA phosphorylates TP53 (Mus musculus)
CDK2 phosphorylates TP53 (Mus musculus)
MAPKAPK5 phosphorylates TP53 (Mus musculus)
TP53 binds STK11 and NUAK1 (Mus musculus)
TP53 binds HIPK1 (Mus musculus)
CDK5 phosphorylates TP53 (Mus musculus)
TAF1 phosphorylates TP53 (Mus musculus)
MDM2 binds TP53 (Mus musculus)
AMPK phosphorylates TP53 (Mus musculus)
TP53RK phosphorylates TP53 (Mus musculus)
ATM phosphorylates TP53 at S15 (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
as a component of
RUNX3:TP53 tetramer [nucleoplasm] (Mus musculus)
TP53:BANP [nucleoplasm] (Mus musculus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Mus musculus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Mus musculus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Mus musculus)
as an output of
USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
TP53 forms homotetramers (Mus musculus)
Inferred From
TP53 Tetramer [nucleoplasm]
(Homo sapiens)
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