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Ctnnb1 [nucleoplasm]
Stable Identifier
R-MMU-3451168
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
CTNNB1, Q02248
Locations in the PathwayBrowser for interactor UniProt:P45481 Crebbp
Expand all
Signal Transduction (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Beta-catenin translocates to the nucleus (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
Deactivation of the beta-catenin transactivating complex (Mus musculus)
Beta-catenin binds SOX proteins (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
CBY1 binds beta-catenin (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
CTNNBIP1 binds beta-catenin (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
Formation of the beta-catenin:TCF transactivating complex (Mus musculus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)
Ctnnb1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q02248 Ctnnb1
Gene Names
Ctnnb1, Catnb
Chain
initiator methionine:, chain:2-781
Reference Genes
BioGPS Gene:12387 Ctnnb1
ENSEMBL:ENSMUSG00000006932.18 Ctnnb1
KEGG Gene (Mus musculus):12387 Ctnnb1
Monarch:12387 Ctnnb1
NCBI Gene:12387 Ctnnb1
UCSC:Q02248 Ctnnb1
Reference Transcript
RefSeq:NM_007614.3 Ctnnb1
RefSeq:NM_001165902.1 Ctnnb1
Other Identifiers
10590325
12387
1420811_a_at
1430533_a_at
1450008_a_at
160430_at
17523257
4313560
4400098
4521457
4609610
4627206
4652805
4757991
4761923
4769382
5003908
5142509
5207424
5349730
5405072
5420945
5441155
5513949
5565038
5591510
A_51_P272046
A_52_P424585
GE33471
GO:0000122
GO:0000165
GO:0000209
GO:0000278
GO:0000578
GO:0000791
GO:0000902
GO:0000922
GO:0001221
GO:0001222
GO:0001501
GO:0001569
GO:0001570
GO:0001649
GO:0001658
GO:0001701
GO:0001702
GO:0001706
GO:0001708
GO:0001711
GO:0001764
GO:0001822
GO:0001840
GO:0001894
GO:0001944
GO:0002052
GO:0002053
GO:0002062
GO:0002067
GO:0002089
GO:0002376
GO:0003151
GO:0003223
GO:0003266
GO:0003338
GO:0003340
GO:0003676
GO:0003682
GO:0003713
GO:0005102
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0005923
GO:0005938
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006790
GO:0007010
GO:0007155
GO:0007160
GO:0007268
GO:0007398
GO:0007399
GO:0007403
GO:0007405
GO:0007507
GO:0008104
GO:0008283
GO:0008284
GO:0008285
GO:0008543
GO:0009410
GO:0009948
GO:0009950
GO:0009953
GO:0009954
GO:0010463
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0010909
GO:0012501
GO:0014010
GO:0014704
GO:0016020
GO:0016055
GO:0016192
GO:0016323
GO:0016324
GO:0016327
GO:0016328
GO:0016331
GO:0016342
GO:0016525
GO:0016600
GO:0016922
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021819
GO:0021854
GO:0022009
GO:0022405
GO:0022414
GO:0023052
GO:0030018
GO:0030027
GO:0030054
GO:0030097
GO:0030154
GO:0030163
GO:0030182
GO:0030217
GO:0030316
GO:0030324
GO:0030331
GO:0030539
GO:0030856
GO:0030858
GO:0030877
GO:0030900
GO:0030901
GO:0030902
GO:0030997
GO:0031016
GO:0031069
GO:0031253
GO:0031396
GO:0031528
GO:0031625
GO:0031641
GO:0031965
GO:0032200
GO:0032212
GO:0032331
GO:0032355
GO:0032968
GO:0032991
GO:0032993
GO:0033077
GO:0033234
GO:0034097
GO:0034330
GO:0034332
GO:0034333
GO:0034394
GO:0034750
GO:0035050
GO:0035112
GO:0035115
GO:0035116
GO:0035255
GO:0036023
GO:0036211
GO:0036520
GO:0042127
GO:0042129
GO:0042475
GO:0042733
GO:0042734
GO:0042981
GO:0042995
GO:0043065
GO:0043066
GO:0043161
GO:0043198
GO:0043226
GO:0043231
GO:0043296
GO:0043410
GO:0043524
GO:0043525
GO:0043588
GO:0043627
GO:0044325
GO:0044338
GO:0044877
GO:0045177
GO:0045202
GO:0045211
GO:0045294
GO:0045296
GO:0045453
GO:0045595
GO:0045596
GO:0045597
GO:0045603
GO:0045667
GO:0045669
GO:0045670
GO:0045671
GO:0045743
GO:0045892
GO:0045893
GO:0045944
GO:0045976
GO:0046332
GO:0048469
GO:0048471
GO:0048489
GO:0048513
GO:0048538
GO:0048568
GO:0048599
GO:0048617
GO:0048643
GO:0048660
GO:0048664
GO:0048709
GO:0048715
GO:0048856
GO:0048870
GO:0050767
GO:0050768
GO:0050808
GO:0050998
GO:0051145
GO:0051450
GO:0051884
GO:0051963
GO:0060038
GO:0060066
GO:0060070
GO:0060173
GO:0060439
GO:0060440
GO:0060441
GO:0060479
GO:0060484
GO:0060485
GO:0060487
GO:0060492
GO:0060742
GO:0060767
GO:0060769
GO:0060789
GO:0060856
GO:0060916
GO:0060947
GO:0060982
GO:0060983
GO:0061047
GO:0061154
GO:0061198
GO:0061549
GO:0061550
GO:0061629
GO:0070097
GO:0070160
GO:0070161
GO:0070369
GO:0070411
GO:0070602
GO:0071260
GO:0071363
GO:0071681
GO:0071944
GO:0072033
GO:0072053
GO:0072054
GO:0072079
GO:0072089
GO:0072132
GO:0072182
GO:0072497
GO:0090090
GO:0090279
GO:0090425
GO:0090575
GO:0097091
GO:0097190
GO:0097718
GO:0098609
GO:0098685
GO:0098772
GO:0098831
GO:0098978
GO:0099092
GO:0140110
GO:0140297
GO:0140677
GO:1901135
GO:1901331
GO:1903377
GO:1904888
GO:1904948
GO:1990138
GO:1990226
GO:1990314
GO:1990403
GO:1990711
GO:1990791
GO:1990907
GO:1990909
GO:1990963
GO:2000008
GO:2000017
GO:2000179
GO:2000288
GO:2000648
GO:2001234
ILMN_2696575
ILMN_2994460
m90364_s_at
mMC007707
Participates
as a component of
TCF/LEF:CTNNB1 [nucleoplasm] (Mus musculus)
CTNNBIP1:CTNNB1 [nucleoplasm] (Mus musculus)
CTNNB1:CHD8 [nucleoplasm] (Mus musculus)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Mus musculus)
CBY1:CTNNB1 [nucleoplasm] (Mus musculus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Mus musculus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Mus musculus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Mus musculus)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Mus musculus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Mus musculus)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Mus musculus)
TCF/LEF:CTNNB1 [nucleoplasm] (Mus musculus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm] (Mus musculus)
TCF/LEF:CTNNB1 [nucleoplasm] (Mus musculus)
as an input of
CTNNBIP1 binds beta-catenin (Mus musculus)
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Mus musculus)
Beta-catenin binds SOX proteins (Mus musculus)
CBY1 binds beta-catenin (Mus musculus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)
as an output of
Beta-catenin translocates to the nucleus (Mus musculus)
Other forms of this molecule
phospho-Ctnnb1 [cytosol]
phospho-Ctnnb1 [nucleoplasm]
Ctnnb1 [plasma membrane]
Ctnnb1 [plasma membrane]
Ctnnb1 [cytosol]
Ctnnb1 [cytosol]
Ctnnb1 [cytosol]
Ctnnb1 [nucleoplasm]
phospho-Ctnnb1 [cytosol]
beta-catenin [cytosol]
phospho-Ctnnb1 [cytosol]
phospho-Ctnnb1 [cytosol]
phospho-Ctnnb1 [cytosol]
Inferred From
CTNNB1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001159374.1
,
NP_031640.1
Ensembl
ENSMUSG00000006932
,
ENSMUST00000007130
,
ENSMUSP00000136294
,
ENSMUST00000178812
,
ENSMUSP00000007130
PRO
Q02248
MGI
88276
PDB
1M1E
,
1V18
,
1DOW
,
1I7X
,
1I7W
,
3OUX
,
3OUW
,
3BCT
,
4EVA
,
4EV8
,
2BCT
,
4EVT
,
4EV9
,
1JPP
,
4EVP
,
4ONS
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09803 Cdh1
6
CDH1(155-700) [plasma membrane]
(R-MMU-2534244)
CDH1(701-882) [extracellular region]
(R-MMU-2534158)
Cdh1(157-884) [plasma membrane]
(R-MMU-199081)
CDH1(155-750) [plasma membrane]
(R-MMU-202940)
CDH1(751-882) [plasma membrane]
(R-MMU-202929)
CDH1(155-882) [plasma membrane]
(R-MMU-198003)
0.897
17
UniProt:O35625 Axin1
8
Phospho Axin1 [cytosol]
(R-MMU-206175)
Axin1 [cytosol]
(R-MMU-4641133)
phospho-Axin1 [cytosol]
(R-MMU-3640864)
phospho-Axin1 [cytosol]
(R-MMU-3640841)
Axin1 [cytosol]
(R-MMU-205727)
Phospho (3 sites) Axin1 [cytosol]
(R-MMU-205737)
phospho-Axin1 [cytosol]
(R-MMU-206040)
Axin1 [cytosol]
(R-MMU-195249)
0.725
9
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.623
8
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.623
3
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.623
7
UniProt:Q9DBG9
1
Tax1bp3 [cytosol]
(R-MMU-5666217)
0.611
6
UniProt:P26231 Ctnna1
3
unfolded KIF13A [cytosol]
(R-MMU-391268)
Ctnna1 [cytosol]
(R-MMU-191697)
Ctnna1 [plasma membrane]
(R-MMU-9761459)
0.609
2
UniProt:Q9JJN6
1
Ctnnbip1 [nucleoplasm]
(R-MMU-3772388)
0.593
5
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.589
3
UniProt:Q924A0 Tcf7l2
3
Tcf7l2 [nucleoplasm]
(R-MMU-9823742)
phospho-Tcf7l2 [nucleoplasm]
(R-MMU-4411392)
Tcf7l2 [nucleoplasm]
(R-MMU-201923)
0.564
5
UniProt:O15047 SETD1A
1
SETD1A [nucleoplasm]
(R-HSA-3239027)
0.544
2
UniProt:P83510
1
TNIK [cytosol]
(R-MMU-3214889)
0.527
3
UniProt:P33148 CADHF
0.525
4
UniProt:P97458 PROP1
0.524
2
UniProt:F1MSG6
1
RAPGEF2 [cytosol]
(R-BTA-5672599)
0.499
2
UniProt:Q04207
7
Rela [nucleoplasm]
(R-MMU-8865233)
phospho-Rela [nucleoplasm]
(R-MMU-9861499)
phospho-Rela [nucleoplasm]
(R-MMU-5660642)
Rela [nucleoplasm]
(R-MMU-177676)
Rela [cytosol]
(R-MMU-168172)
Rela [nucleoplasm]
(R-MMU-4755466)
phospho-Rela [nucleoplasm]
(R-MMU-5624468)
0.499
5
UniProt:O54826 AF10
0.499
2
UniProt:P28828 PTPRM
0.499
2
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
UniProt:P35569 Irs1
8
p-Irs1 [cytosol]
(R-MMU-2671869)
phospho-Irs1 [plasma membrane]
(R-MMU-2445090)
Irs1 [plasma membrane]
(R-MMU-2425392)
Phospho-IRS1 (by NTRK1) [cytosol]
(R-MMU-198285)
Irs1 [cytosol]
(R-MMU-198257)
Irs1 [cytosol]
(R-MMU-74769)
phospho-Irs1 [cytosol]
(R-MMU-74772)
phospho-Irs1 [plasma membrane]
(R-MMU-198366)
0.462
2
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