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Casp8 [cytosol]
Stable Identifier
R-MMU-3465404
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CASP8(1-374), O89110
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signalling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)
Casp8 [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O89110
Gene Names
Casp8
Reference Genes
BioGPS Gene:12370 Casp8
ENSEMBL:ENSMUSG00000026029
ENSEMBL:ENSMUSG00000026029 Casp8
KEGG Gene (Mus musculus):12370 Casp8
Monarch:12370 Casp8
NCBI Gene:12370 Casp8
UCSC:O89110 Casp8
Reference Transcript
RefSeq:NM_009812.2 Casp8
RefSeq:NM_001080126.1 Casp8
Other Identifiers
102328_at
10346564
12370
1424552_at
17213213
4414187
4466287
4605085
4746757
4857306
5020777
5033743
5086615
5215711
5464876
5566874
5567361
A_51_P247799
GE41643
GO:0003674
GO:0004197
GO:0005515
GO:0006508
GO:0008150
GO:0008219
GO:0008233
GO:0008234
GO:0042981
ILMN_1243876
ILMN_3097868
Msa.28381.0_s_at
mMC023356
Participates
as a component of
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Mus musculus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
Other forms of this molecule
Casp8 [mitochondrial outer membrane]
Casp8 [mitochondrial outer membrane]
Casp8 [cytosol]
Casp8 [cytosol]
Casp8 [cytosol]
Inferred From
CASP8(1-374) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033942.1
,
NP_001073595.1
IntEnz
3.4.22.61
Ensembl
ENSMUSP00000127375
,
ENSMUST00000165549
,
ENSMUSP00000027189
,
ENSMUST00000027189
,
ENSMUSG00000026029
PRO
O89110
MGI
1261423
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.813
6
UniProt:P25446
1
Fas [plasma membrane]
(R-MMU-66248)
0.669
3
UniProt:Q9D8Y7
1
Tnfaip8l2 [cytosol]
(R-MMU-8874472)
0.524
2
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
2
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