Reactome | phospho-Axin1 [cytosol]

phospho-Axin1 [cytosol]

Stable Identifier

R-MMU-3640864

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Ub-RibC-AXIN1, O35625

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Deubiquitination (Mus musculus)
    - Ub-specific processing proteases (Mus musculus)
      - USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)
        
        Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Mus musculus)
        
        Ub-RibC-AXIN [cytosol] (Mus musculus)
        
        phospho-Axin1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O35625 Axin1

Gene Names

Axin1, Axin, Fu

Chain

chain:1-863

Reference Genes

BioGPS Gene:12005 Axin1

KEGG:mmu:12005 Axin1

Monarch:12005 Axin1

NCBI Gene:12005 Axin1

UCSC:O35625 Axin1

Reference Transcript

RefSeq:NM_009733.2 Axin1

Other Identifiers

10442954

114132_f_at

12005

1426966_at

1426967_at

160701_at

17334869

4348244

4391916

4563112

4580430

4636102

4671161

4779344

4800534

4817887

4880203

5179162

5238929

5249717

5429476

5433268

5548527

AF009011_s_at

A_52_P197007

A_55_P2143209

GE33184

GO:0000209

GO:0001701

GO:0001932

GO:0001934

GO:0002039

GO:0005102

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0006325

GO:0006355

GO:0006913

GO:0006915

GO:0007010

GO:0007605

GO:0008013

GO:0009950

GO:0009953

GO:0010629

GO:0010800

GO:0012501

GO:0015630

GO:0016055

GO:0016328

GO:0019899

GO:0019901

GO:0019904

GO:0030163

GO:0030178

GO:0030511

GO:0030877

GO:0031122

GO:0031398

GO:0031410

GO:0031625

GO:0032436

GO:0032991

GO:0033138

GO:0034244

GO:0036342

GO:0042802

GO:0042803

GO:0043161

GO:0043226

GO:0044725

GO:0045202

GO:0045599

GO:0045732

GO:0045860

GO:0046330

GO:0046332

GO:0048318

GO:0048320

GO:0048468

GO:0048471

GO:0048856

GO:0050877

GO:0051248

GO:0060070

GO:0060090

GO:0060322

GO:0060828

GO:0065003

GO:0070016

GO:0070411

GO:0070412

GO:0071944

GO:0090090

GO:1990756

GO:1990909

GO:2000060

ILMN_1217662

ILMN_1246329

mMC008865

Participates

as a member of

Ub-RibC-AXIN [cytosol] (Mus musculus)

Other forms of this molecule

Phospho Axin1 [cytosol]

phospho-Axin1 [cytosol]

Axin1 [cytosol]

Phospho (3 sites) Axin1 [cytosol]

phospho-Axin1 [cytosol]

Axin1 [cytosol]

Inferred From

Ub-RibC-AXIN1 [cytosol] (Homo sapiens)

Modified Residues

Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position

PsiMod Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue

PsiMod Definition

A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_033863.2

ENSEMBL

ENSMUST00020183805, ENSMUSP00001091662, ENSMUSP00000073974, ENSMUST00000074370

PRO

O35625

MGI

1096327

PDB

3UTM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [plasma membrane] (R-MMU-9761458) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926)	0.725	9
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.688	4
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.659	5
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.656	4
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.589	2
UniProt:Q9WV60 Gsk3b	3	GSK3beta [cytosol] (R-MMU-206095) Gsk3b [nucleoplasm] (R-MMU-182565) GSK3B [cytosol] (R-MMU-2997551)	0.589	2
UniProt:Q99ML9 Rnf111	3	RNF111 [cytosol] (R-MMU-975981) Rnf111 [nucleoplasm] (R-MMU-2186735) RNF111 [nucleoplasm] (R-MMU-2186765)	0.581	4
UniProt:O95271 TNKS	1	TNKS [cytosol] (R-HSA-3640825)	0.581	4
UniProt:O88572	5	Lrp6 [early endosome membrane] (R-MMU-5368481) phospho-Lrp6 [early endosome membrane] (R-MMU-5368496) phospho-Lrp6 [plasma membrane] (R-MMU-1458894) phospho-Lrp6 [plasma membrane] (R-MMU-1458895) Lrp6 [plasma membrane] (R-MMU-206252)	0.527	5
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.524	3
UniProt:Q61062	4	Dvl3 [cytosol] (R-MMU-4652688) Dvl3 [cytosol] (R-MMU-201678) phospho-Dvl3 [cytosol] (R-MMU-201680) phospho-Dvl3 [cytosol] (R-MMU-3772400)	0.499	2
UniProt:Q9EPK5 Wwtr1	4	Wwtr1 [nucleoplasm] (R-MMU-2064930) phospho-Wwtr1 [cytosol] (R-MMU-2028665) Wwtr1 [cytosol] (R-MMU-1629773) Wwtr1 [nucleoplasm] (R-MMU-1629775)	0.499	4

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