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Dock1 [cytosol]
Stable Identifier
R-MMU-372654
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
DOCK1, Q8BUR4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
Netrin-1 signaling (Mus musculus)
DCC mediated attractive signaling (Mus musculus)
Activation of Cdc42 (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Activation of Rac1 (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
RhoGTPase GEF's recruited to DCC (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Factors involved in megakaryocyte development and platelet production (Mus musculus)
DOCKs bind to RhoGEFs (Mus musculus)
DOCK-GEFs [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Mus musculus)
DOCK-GEFs [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
Activation of RAC1 by the PXN:CRK complex (Mus musculus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Phosphorylated PXN recruits the CRK complex (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
DOCK180:ELMO binds CRK (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
RAC2 GTPase cycle (Mus musculus)
RAC2 GEFs activate RAC2 (Mus musculus)
RAC2 GEFs [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
RHOG GTPase cycle (Mus musculus)
RHOG binds effectors at the plasma membrane (Mus musculus)
RHOG plasma membrane effectors [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Mus musculus)
RHOG plasma membrane effectors [cytosol] (Mus musculus)
Dock1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8BUR4
Gene Names
Dock1
Reference Genes
BioGPS Gene:330662 Dock1
ENSEMBL:ENSMUSG00000058325
ENSEMBL:ENSMUSG00000058325.7 Dock1
KEGG Gene (Mus musculus):330662 Dock1
Monarch:330662 Dock1
NCBI Gene:330662 Dock1
UCSC:Q8BUR4 Dock1
Reference Transcript
RefSeq:NM_001033420.2 Dock1
Other Identifiers
10558345
114940_at
1443991_at
1452220_at
163609_at
17484167
330662
4311674
4340495
4395408
4403466
4455864
4457731
4466407
4498708
4512948
4516604
4539371
4541919
4556883
4580106
4583058
4590920
4608576
4613914
4617020
4619750
4623769
4675649
4686467
4691252
4712533
4718332
4728830
4759291
4760292
4763683
4771987
4777135
4792447
4817215
4914783
4972624
4997350
5067542
5135135
5161258
5265252
5277504
5279862
5344027
5368537
5383493
5394380
5397567
5402384
5440925
5441096
5492951
5508205
5532305
5556110
5584341
5597655
A_51_P373163
A_52_P660922
A_55_P2728297
A_55_P2734687
A_55_P2794361
GE1413207
GO:0002244
GO:0005085
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006909
GO:0006915
GO:0007155
GO:0007264
GO:0007520
GO:0010634
GO:0012501
GO:0016020
GO:0016192
GO:0016477
GO:0016607
GO:0017124
GO:0023052
GO:0030154
GO:0031267
GO:0032045
GO:0043226
GO:0048856
GO:0048870
GO:0098772
GO:1900026
ILMN_1250773
ILMN_2525344
ILMN_2885196
mMC016491
Participates
as a candidate of
RAC2 GEFs [cytosol] (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
as a member of
RHOG plasma membrane effectors [cytosol] (Mus musculus)
DOCK-GEFs [cytosol] (Mus musculus)
DOCK1,TRIO [cytosol] (Mus musculus)
as a component of
DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
Inferred From
DOCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001028592.1
Ensembl
ENSMUST00000084488
,
ENSMUSP00000081531
,
ENSMUSG00000058325
PRO
Q8BUR4
MGI
2429765
PDB
2M0Y
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