Reactome | Nuf2 [cytosol]

Nuf2 [cytosol]

Stable Identifier

R-MMU-375300

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

NUF2, Q99P69

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
  - Signaling by Rho GTPases (Mus musculus)
    - RHO GTPase Effectors (Mus musculus)
      - RHO GTPases Activate Formins (Mus musculus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        KMN network [cytosol] (Mus musculus)
        
        NDC80 complex [cytosol] (Mus musculus)
        
        Nuf2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99P69

Gene Names

Nuf2

Reference Genes

BioGPS Gene:66977 Nuf2

ENSEMBL:ENSMUSG00000026683

ENSEMBL:ENSMUSG00000026683.15 Nuf2

KEGG Gene (Mus musculus):66977 Nuf2

Monarch:66977 Nuf2

NCBI Gene:66977 Nuf2

UCSC:Q99P69 Nuf2

Reference Transcript

Other Identifiers

10359890

106256_at

1430811_a_at

17229433

4350018

4481006

4622150

4730431

4751556

4754125

4776603

4854867

5027235

5058448

5122848

5144627

5150190

5232261

5279206

5362450

5364024

5479872

5587387

5604664

66977

A_51_P513682

A_55_P2174704

GE40418

GO:0000278

GO:0000775

GO:0000776

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007094

GO:0008017

GO:0008092

GO:0008608

GO:0022414

GO:0023052

GO:0031262

GO:0043226

GO:0044877

GO:0045132

GO:0051301

GO:0051315

GO:0051383

GO:0140013

GO:0140014

ILMN_2755241

ILMN_2755242

mMC015845

Participates

as a component of

NDC80 complex [cytosol] (Mus musculus)

Inferred From

NUF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_075773.2, XP_006497021.1

Ensembl

ENSMUSP00000106999, ENSMUSP00000028000, ENSMUSG00000026683, ENSMUST00000028000, ENSMUST00000111368

PRO

Q99P69

MGI

1914227

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