Reactome | Cep250 [cytosol]

Cep250 [cytosol]

Stable Identifier

R-MMU-380263

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CEP250, Q60952

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Mus musculus)

- Cilium Assembly (Mus musculus)
  - Anchoring of the basal body to the plasma membrane (Mus musculus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - C2CD3 binds the mother centriole (Mus musculus)
      - mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - CP110 and CEP97 dissociate from the centriole (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - MARK4 binds ODF2 in the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - Recruitment of transition zone proteins (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
    - The distal appendage proteins recruit TTBK2 (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep250 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60952

Gene Names

Cep250

Reference Genes

BioGPS Gene:16328 Cep250

ENSEMBL:ENSMUSG00000038241

ENSEMBL:ENSMUSG00000038241.17 Cep250

KEGG Gene (Mus musculus):16328 Cep250

Monarch:16328 Cep250

NCBI Gene:16328 Cep250

UCSC:Q60952 Cep250

Reference Transcript

Other Identifiers

101145_at

10477739

1421512_at

16328

17378468

4317273

4343845

4356915

4380525

4402904

4412411

4438903

4447495

4450026

4470555

4491460

4492655

4502666

4505168

4523464

4565924

4628945

4631461

4635586

4653122

4762406

4773501

4780872

4780969

4803940

4813110

4814767

4839697

4859175

4904136

4908901

4960787

5025477

5041623

5095516

5098994

5108290

5140224

5228898

5257060

5274058

5306116

5321428

5345676

5349496

5429243

5524191

5527792

5542935

A_51_P191087

A_52_P648696

A_55_P2175190

A_66_P101003

GO:0000278

GO:0001750

GO:0001917

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005856

GO:0005929

GO:0007010

GO:0007049

GO:0008104

GO:0010457

GO:0019904

GO:0030030

GO:0030997

GO:0031616

GO:0032991

GO:0033365

GO:0036064

GO:0042995

GO:0043226

GO:0044782

GO:0048471

GO:0050877

GO:0050908

GO:0060271

GO:0071539

GO:1904781

GO:1905515

ILMN_1213506

ILMN_1216380

U33198_s_at

mMC011205

Participates

as a component of

as an output of

Loss of C-Nap-1 from centrosomes (Mus musculus)

Inferred From

CEP250 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032409.3, NP_001123471.1, NP_796191.2

Ensembl

ENSMUST00000094421, ENSMUSP00000091988, ENSMUSG00000038241

PRO

Q60952

MGI

108084

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