Reactome | Avp [extracellular region]

Avp [extracellular region]

Stable Identifier

R-MMU-388474

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

AVP(20-28), P35455

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - ADBRK1,2 phosphorylate AVPR2 (Mus musculus)
        
        AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - ARRB bind GPCRs (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - SNX9 recruits components of the actin polymerizing machinery (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        ARRB-binding GPCRs [plasma membrane] (Mus musculus)
        
        p-AVPR2:AVP(20-28) [plasma membrane] (Mus musculus)
        
        Avp [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P35455 Avp

Gene Names

Avp

Chain

signal peptide:1-23, peptide:24-32, chain:36-128, peptide:130-168

Reference Genes

BioGPS Gene:11998 Avp

ENSEMBL:ENSMUSG00000037727 Avp

KEGG Gene (Mus musculus):11998 Avp

Monarch:11998 Avp

NCBI Gene:11998 Avp

UCSC:P35455 Avp

Reference Transcript

RefSeq:NM_009732.2 Avp

Other Identifiers

10487685

11998

1450794_at

17391665

4654007

4766734

4855987

5089352

5279140

5406618

93381_at

A_51_P136508

GE35103

GO:0003674

GO:0005185

GO:0005575

GO:0005576

ILMN_2710928

M88354_s_at

mMC018816

Participates

as a component of

as a member of

as an input of

Other forms of this molecule

Avp [clathrin-coated endocytic vesicle membrane]

Avp [cytosol]

Avp [extracellular region]

Inferred From

AVP(20-28) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_033862.1

Ensembl

ENSMUSP00000035551, ENSMUSG00000037727, ENSMUST00000046001

PRO

P35455

MGI

88121

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