Reactome | phospho-Cd28 [plasma membrane]

phospho-Cd28 [plasma membrane]

Stable Identifier

R-MMU-388756

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

p-Y191-CD28, P31041

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
        
        Phospho CD28 homodimer [plasma membrane] (Mus musculus)
        
        phospho-Cd28 [plasma membrane] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Mus musculus)
        
        Phospho CD28 homodimer [plasma membrane] (Mus musculus)
        
        phospho-Cd28 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P31041

Gene Names

Cd28

Reference Genes

BioGPS Gene:12487 Cd28

ENSEMBL:ENSMUSG00000026012

ENSEMBL:ENSMUSG00000026012.3 Cd28

KEGG Gene (Mus musculus):12487 Cd28

Monarch:12487 Cd28

NCBI Gene:12487 Cd28

UCSC:P31041 Cd28

Reference Transcript

RefSeq:NM_007642.4 Cd28

Other Identifiers

102237_at

10346783

12487

1417597_at

1437025_at

1443703_at

17213462

4421087

4788106

4932168

5127484

5410485

5509531

5542342

5550686

A_52_P162967

A_55_P1979491

GE34823

GO:0000278

GO:0001772

GO:0002020

GO:0002376

GO:0002863

GO:0005886

GO:0006310

GO:0006351

GO:0006355

GO:0006366

GO:0006954

GO:0006955

GO:0007155

GO:0009897

GO:0009986

GO:0010628

GO:0010629

GO:0012501

GO:0016020

GO:0019901

GO:0023052

GO:0030154

GO:0031295

GO:0032733

GO:0032743

GO:0032753

GO:0035739

GO:0042098

GO:0042102

GO:0042110

GO:0042129

GO:0042802

GO:0043491

GO:0045060

GO:0045066

GO:0045589

GO:0045840

GO:0045944

GO:0048304

GO:0048856

GO:0050852

GO:0051897

GO:0097190

GO:0098636

GO:0140014

GO:2000563

ILMN_2589865

ILMN_2589871

ILMN_2591361

m34563_s_at

mMC008873

Participates

as a component of

Phospho CD28 homodimer [plasma membrane] (Mus musculus)

Other forms of this molecule

Cd28 [plasma membrane]

Inferred From

p-Y191-CD28 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 191 (in Homo sapiens)

Coordinate

191

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_031668.3

Ensembl

ENSMUSG00000026012, ENSMUSP00000027165, ENSMUST00000027165

PRO

P31041

MGI

88327

PDB

2NAE

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