Sumoylation of Ppargc1a with Sumo1

Stable Identifier
R-MMU-3903005
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sumoylation of Ppargc1a with Sumo1

Ppargc1a (Pgc-1alpha) is sumoylated at lysine-183 with Sumo1 (Rytinki et al. 2009, Cai et al. 2012). Sumoylation reduces transcription activation by Ppargc1a.

Literature References
PubMed ID Title Journal Year
23152500 SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1?

Cai, R, Yu, T, Huang, C, Xia, X, Liu, X, Gu, J, Xue, S, Yeh, ET, Cheng, J

J. Biol. Chem. 2012
19625249 SUMOylation attenuates the function of PGC-1alpha

Rytinki, MM, Palvimo, JJ

J. Biol. Chem. 2009
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Sumo1:C93-Ube2i [nucleoplasm]

Physical Entity
Sumo1:C93-Ube2i [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of PPARGC1A with SUMO1 (Homo sapiens)
Authored
May, B  (2013-07-15)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-17)
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