Reactome | Htr4 [plasma membrane]

Htr4 [plasma membrane]

Stable Identifier

R-MMU-391008

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

HTR4, P97288

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        HTR4,6,7:5HT [plasma membrane] (Mus musculus)
        
        HTR4,6,7 [plasma membrane] (Mus musculus)
        
        Htr4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        HTR4,6,7:5HT [plasma membrane] (Mus musculus)
        
        HTR4,6,7 [plasma membrane] (Mus musculus)
        
        Htr4 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Serotonin receptors (Mus musculus)
        
        5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)
        
        HTR4,6,7 [plasma membrane] (Mus musculus)
        
        Htr4 [plasma membrane] (Mus musculus)
        
        HTR4,6,7:5HT [plasma membrane] (Mus musculus)
        
        HTR4,6,7 [plasma membrane] (Mus musculus)
        
        Htr4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P97288

Gene Names

Htr4

Reference Genes

BioGPS Gene:15562 Htr4

ENSEMBL:ENSMUSG00000026322

ENSEMBL:ENSMUSG00000026322 Htr4

KEGG Gene (Mus musculus):15562 Htr4

Monarch:15562 Htr4

NCBI Gene:15562 Htr4

UCSC:P97288 Htr4

Reference Transcript

Other Identifiers

10456161

1427654_a_at

1443365_at

15562

17351168

4369892

4444438

4544540

4605101

4706241

4795942

4955384

4971141

4985929

4998064

5091460

5095034

5225887

5458539

5470698

5612882

95321_at

95322_g_at

95323_at

A_51_P346353

A_52_P581594

A_55_P1990400

GE117961

GO:0003674

GO:0004930

GO:0004993

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0007198

GO:0007214

GO:0007267

GO:0007268

GO:0008150

GO:0016020

GO:0016021

GO:0030425

GO:0030594

GO:0031410

GO:0032098

GO:0043167

GO:0043226

GO:0045202

GO:0051378

ILMN_1231481

ILMN_2440767

ILMN_2743188

ILMN_2776236

ILMN_2776237

Msa.3263.0_s_at

mMC015874

mMR027625

Participant Of

hasMember

HTR4,6,7 [plasma membrane]

Inferred From

HTR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_032339.2, XP_006525743.1, XP_017173328.1, XP_006525746.1, XP_006525741.1, XP_006525739.1

ZINC - Substances

5HT4R_MOUSE

Ensembl

ENSMUSP00000157967, ENSMUST00000236691, ENSMUST00000027560, ENSMUST00000238081, ENSMUSG00000026322, ENSMUSP00000157470, ENSMUSP00000027560

ZINC target

P97288

PRO

P97288

ZINC - Predictions - Purchasable

5HT4R_MOUSE

MGI

109246

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34947 GRK5	1	GRK5 [plasma membrane] (R-HSA-416468)	0.632	8
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.544	2
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	5