Reactome | Fbxw9 [cytosol]

Fbxw9 [cytosol]

Stable Identifier

R-MMU-391290

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

FBXW9, F8VPX2

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw9 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:F8VPX2

Gene Names

Fbxw9

Reference Genes

BioGPS Gene:68628 Fbxw9

ENSEMBL:ENSMUSG00000008167

ENSEMBL:ENSMUSG00000008167.15 Fbxw9

KEGG Gene (Mus musculus):68628 Fbxw9

Monarch:68628 Fbxw9

NCBI Gene:68628 Fbxw9

UCSC:F8VPX2 Fbxw9

Reference Transcript

RefSeq:NM_026791.2 Fbxw9

Other Identifiers

10573549

115381_at

1428120_at

168470_f_at

17503362

4463917

4643766

4648946

4679659

4786299

4790871

4792393

4815018

4819238

4847630

4922967

4990385

5167558

5193181

5278256

5402797

68628

A_51_P357561

GE103087

GO:0005515

ILMN_1256495

mMC007095

Participates

as a member of

F-box protein [cytosol] (Mus musculus)

Inferred From

FBXW9 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_081067.2

Ensembl

ENSMUSP00000092845, ENSMUSG00000008167, ENSMUST00000095220

MGI

1915878

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