Reactome | FBXL5 [cytosol]

FBXL5 [cytosol]

Stable Identifier

R-MMU-391295

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q8C2S5

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        FBXL5 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8C2S5

Reference Genes

BioGPS Gene:242960

ENSEMBL:ENSMUSG00000039753

ENSEMBL:ENSMUSG00000039753.17

KEGG Gene (Mus musculus):242960

Monarch:242960

NCBI Gene:242960

UCSC:Q8C2S5

Reference Transcript

Other Identifiers

10529801

1433441_at

163700_at

17447803

242960

4351300

4434559

4450249

4478650

4506231

4594190

4664237

4717744

4840491

4875066

5017150

5036392

5041962

5069240

5221790

5227110

5252751

5301432

5388326

5398857

5439813

5542805

96031_r_at

A_52_P39533

A_52_P617963

A_52_P626052

A_55_P1965194

A_55_P1965200

A_55_P2490544

GO:0005506

GO:0005515

GO:0005634

GO:0005737

GO:0006879

GO:0016567

GO:0019005

GO:0030163

GO:0031146

GO:0036211

GO:0043226

GO:0045732

GO:0046872

GO:0048471

GO:0051536

GO:0055065

GO:0055080

GO:0060586

GO:0098771

ILMN_1238032

ILMN_2560594

ILMN_2662020

ILMN_2663534

ILMN_2797374

mMC002488

mMC022637

mMR030694

Participates

as an input of

CUL1, SKP1, FBXL5 bind (Mus musculus)

as a component of

SKP1:CUL1:FBXL5 [cytosol] (Mus musculus)

as a member of

F-box protein [cytosol] (Mus musculus)

Inferred From

FBXL5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001153435.1, NP_848844.1

Ensembl

ENSMUST00000196483, ENSMUST00000121736, ENSMUST00000047857, ENSMUST00000114047, ENSMUSP00000112444, ENSMUSP00000109681, ENSMUSP00000084733, ENSMUST00000087465, ENSMUSP00000045792, ENSMUSG00000039753, ENSMUSP00000143703

PRO

Q8C2S5

MGI

2152883

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