Reactome | Fbxw4 [cytosol]

Fbxw4 [cytosol]

Stable Identifier

R-MMU-391305

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

FBXW4, Q9JMJ2

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxw4 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9JMJ2

Gene Names

Fbxw4

Reference Genes

BioGPS Gene:30838 Fbxw4

ENSEMBL:ENSMUSG00000040913

ENSEMBL:ENSMUSG00000040913.12 Fbxw4

KEGG Gene (Mus musculus):30838 Fbxw4

Monarch:30838 Fbxw4

NCBI Gene:30838 Fbxw4

UCSC:Q9JMJ2 Fbxw4

Reference Transcript

RefSeq:NM_013907.2 Fbxw4

Other Identifiers

10468059

1417226_at

17365211

30838

4382617

4384149

4431658

4438549

4590779

4681905

4833588

4966211

4987692

5067333

5092652

5149776

5288410

5414766

96768_at

AA182139_s_at

GE41794

GO:0002053

GO:0005515

GO:0016055

GO:0019005

GO:0023052

GO:0030163

GO:0031146

GO:0042733

GO:0048856

GO:0051216

GO:0060173

ILMN_1241696

ILMN_2657986

mMC001997

Participates

as a member of

F-box protein [cytosol] (Mus musculus)

Inferred From

FBXW4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_038935.1

Ensembl

ENSMUSP00000036505, ENSMUSG00000040913, ENSMUST00000046869

PRO

Q9JMJ2

MGI

1354698

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