Sumoylation of Crebbp with Sumo1

Stable Identifier
R-MMU-3927825
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sumoylation of Crebbp with Sumo1

Crebbp (Cbp) is sumoylated at lysine-999, lysine-1034, and lysine-1057 with Sumo1 (Kuo et al. 2005, Ryan et al. 2010, Shih et al. 2007). Sumoylation recruits Daxx and Hdac2 to repress transcription.

Literature References
PubMed ID Title Journal Year
16287980 SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx

Kuo, HY, Chang, CC, Jeng, JC, Hu, HM, Lin, DY, Maul, GG, Kwok, RP, Shih, HM

Proc. Natl. Acad. Sci. U.S.A. 2005
18031230 Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization

Shih, HM, Chang, CC, Kuo, HY, Lin, DY

Biochem. Soc. Trans. 2007
20006587 SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells

Ryan, CM, Kindle, KB, Collins, HM, Heery, DM

Biochem. Biophys. Res. Commun. 2010
Participants
Input
Output
Catalyst Activity

SUMO transferase activity of Sumo1:C93-Ube2i [nucleoplasm]

Physical Entity
Sumo1:C93-Ube2i [nucleoplasm] (Mus musculus)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of CREBBP with SUMO1 (Homo sapiens)
Authored
May, B  (2013-07-17)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-07-21)
Cite Us!