Reactome | monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]

monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]

Stable Identifier

R-MMU-3927936

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CREB-binding protein, CBP_MOUSE, Crebbp

External Reference Information

External Reference

UniProt:P45481 Crebbp

Gene Names

Crebbp, Cbp

Chain

initiator methionine:, chain:2-2441

Participates

as an output of

Sumoylation of Crebbp with Sumo1 (Mus musculus)

Other forms of this molecule

CREBBP [nucleoplasm]

Crebbp [nucleoplasm]

Foxo4-S-S-Crebbp [nucleoplasm]

Modified Residues

Name

sumoylated lysine (monoSumo1 [nucleoplasm]) at 999

Coordinate

999

Modification

monoSumo1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSumo1 [nucleoplasm]) at 1034

Coordinate

1034

Modification

monoSumo1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSumo1 [nucleoplasm]) at 1057

Coordinate

1057

Modification

monoSumo1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

PRO

P45481

MGI

1098280

PDB

2LQI, 1JJS, 6DNQ, 1KBH, 2KKJ, 1SB0, 1TOT, 2LQH, 1U2N, 5W0I, 2L14, 2KA6, 1R8U, 5HPD, 5U4K, 7LVS, 4I9O, 2AGH, 6DMX, 2KA4, 5HP0, 5HOU, 1F81, 2C52, 1KDX, 1L8C, 2LWW, 5U7G

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.845	10
UniProt:Q04207	7	Rela [nucleoplasm] (R-MMU-8865233) phospho-Rela [nucleoplasm] (R-MMU-9861499) phospho-Rela [nucleoplasm] (R-MMU-5660642) Rela [nucleoplasm] (R-MMU-177676) Rela [cytosol] (R-MMU-168172) Rela [nucleoplasm] (R-MMU-4755466) phospho-Rela [nucleoplasm] (R-MMU-5624468)	0.821	10
UniProt:P27577	2	Ets1 [nucleoplasm] (R-MMU-1629809) phospho-Ets1 [nucleoplasm] (R-MMU-3132720)	0.618	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.602	4
UniProt:P88946 P88946			0.593	6
UniProt:Q02248 Ctnnb1	14	phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) Ctnnb1 [plasma membrane] (R-MMU-9761458) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363)	0.589	3
UniProt:Q60749	3	Khdrbs1 [nucleoplasm] (R-MMU-8848941) phospho-Khdrbs1 [cytosol] (R-MMU-8848995) phospho-Khdrbs1 [nucleoplasm] (R-MMU-8848970)	0.581	7
UniProt:Q9WTL8-4 BMAL1			0.558	2
UniProt:P03254 E1A			0.558	3
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.558	7
UniProt:P03255 E1A			0.544	2
UniProt:P61201 COPS2	2	COPS2 [cytosol] (R-HSA-416971) COPS2 [nucleoplasm] (R-HSA-5697012)	0.527	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.524	3
UniProt:Q60680	4	phospho-p-Y187,Y198-CHUK [cytosol] (R-MMU-9861501) phospho-p-T23-CHUK [cytosol] (R-MMU-198615) phospho-p-S176,S180-CHUK [cytosol] (R-MMU-177667) CHUK [cytosol] (R-MMU-168104)	0.508	2
UniProt:Q62318-1 TRIM28			0.499	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.499	7
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.499	3
UniProt:P54843 Maf	1	Maf [nucleoplasm] (R-MMU-8984726)	0.463	2
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.462	2

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