SFKs phosphorylate Git1

Stable Identifier
R-MMU-3928622
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
SFKs phosphorylate Git1
G-protein-coupled receptor kinase-interacting protein 1 (GIT1) has been shown to be critical for spine morphogenesis and synapse formation through assembling and targeting multiprotein signaling complexes, which contain important actin regulators including PIX, Rac GEF, and PAK, between the sub-cellular compartments (Zhang et al. 2003). Activation of ephrinBs (EFNBs) by EPHB receptors may lead to the phosphorylation of GIT1 on Tyr392 (in humans Tyr385, based on sequence similarity). The Src-family kinases (SFKs) recruited to EFNB expression domains are involved in this phosphorylation. Tyr392 in the N-terminal of the SLD domain is required for GIT1s binding to the SH2 domain of GRB4 (Segura et al. 2007).
Literature References
PubMed ID Title Journal Year
17310244 Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

Acker-Palmer, A, Essmann, CL, Weinges, S, Segura, I

Nat. Neurosci. 2007
Participants
Catalyst Activity

protein tyrosine kinase activity of Src [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!